Showing BioInteractions for Valspodar (DB11869)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Valspodar is a Solute carrier organic anion transporter family member 1B1 inhibitor
1Solute carrier organic anion transporter family member 1B1 substratesAmbrisentan, Asunaprevir, Atorvastatin, Axitinib, Benzylpenicillin, Cerivastatin, Cholecystokinin, Cholic Acid, Clotrimazole, Cobimetinib, Conjugated estrogens, Cyclosporine, Digoxin, Dinoprostone, Elagolix, Eluxadoline, Empagliflozin, Erythromycin, Ezetimibe, Fexofenadine, Fimasartan, Fluvastatin, Gadoxetic acid, Gimatecan, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Lovastatin, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paritaprevir, Penicillamine, Pitavastatin, Prasterone, Pravastatin, Raloxifene, Remdesivir, Repaglinide, Revefenacin, Rosuvastatin, Selexipag, Simeprevir, Simvastatin, Sumatriptan, Taurocholic acid, Technetium Tc-99m mebrofenin, Tenofovir alafenamide, Torasemide, Ubrogepant, Valsartan, Voxilaprevir
2Solute carrier organic anion transporter family member 1B1 inhibitorsAcetylcysteine, Aminohippuric acid, Amprenavir, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Axitinib, Beclomethasone dipropionate, Bempedoic acid, Benzbromarone, Bezafibrate, Cabazitaxel, Candesartan, Caspofungin, Cerivastatin, Cholecystokinin, Cholic Acid, Clarithromycin, Clotrimazole, Cobicistat, Conjugated estrogens, Cyclosporine, Dabrafenib, Daclatasvir, Darolutamide, Darunavir, Diclofenac, Diethylstilbestrol, Digoxin, Dipyridamole, Dovitinib, Dronedarone, Elexacaftor, Eltrombopag, Eluxadoline, Enasidenib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Everolimus, Fedratinib, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Gemfibrozil, Genistein, Glecaprevir, Hyperforin, Idelalisib, Indinavir, Indomethacin, Irinotecan, Istradefylline, Ivermectin, Ketoconazole, Lenvatinib, Levocarnitine, Levothyroxine, Lobeglitazone, Lopinavir, Lovastatin, Mifepristone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Novobiocin, Nystatin, Osilodrostat, Ouabain, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Pioglitazone, Pitavastatin, Posizolid, Progesterone, Quercetin, Quinidine, Quinine, Remdesivir, Reserpine, Rifampicin, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Sacubitril, Saquinavir, Sildenafil, Silibinin, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Tacrolimus, Taurocholic acid, Telaprevir, Telithromycin, Teriflunomide, Tipranavir, Troglitazone, Ubrogepant, Upadacitinib, Valsartan, Velpatasvir, Venetoclax, Verapamil, Vinblastine, Vincristine, Voxilaprevir
3Solute carrier organic anion transporter family member 1B1 inducersApalutamide, Cholic Acid, Taurocholic acid
4Solute carrier organic anion transporter family member 1B1 weak inhibitorsCobimetinib
5Solute carrier organic anion transporter family member 1B1 transportersVelpatasvir
Interacting GroupInteracting Drugs
Valspodar is a Solute carrier organic anion transporter family member 1B3 inhibitor
1Solute carrier organic anion transporter family member 1B3 substratesAmbrisentan, Atorvastatin, Bempedoic acid, Caspofungin, Cholecystokinin, Cholic Acid, Cobimetinib, Conjugated estrogens, Docetaxel, Empagliflozin, Erythromycin, Fexofenadine, Fluvastatin, Gadoxetic acid, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paclitaxel, Parachlorophenol, Paritaprevir, Pitavastatin, Prasterone, Pravastatin, Raloxifene, Revefenacin, Rifampicin, Romidepsin, Selexipag, Simeprevir, Sincalide, Taurocholic acid, Technetium Tc-99m mebrofenin, Tenofovir alafenamide, Testosterone, Trastuzumab deruxtecan, Ubrogepant, Valsartan, Voxilaprevir
2Solute carrier organic anion transporter family member 1B3 inhibitorsAsunaprevir, Ataluren, Atazanavir, Baricitinib, Beclomethasone dipropionate, Bempedoic acid, Cabazitaxel, Clarithromycin, Cobicistat, Cobimetinib, Cyclosporine, Dabrafenib, Daclatasvir, Darolutamide, Dipyridamole, Dovitinib, Dronedarone, Elexacaftor, Enasidenib, Erythromycin, Everolimus, Fedratinib, Gemfibrozil, Ginsenoside Rb1, Glecaprevir, Idelalisib, Istradefylline, Ivermectin, Levothyroxine, Lopinavir, Mifepristone, Nefazodone, Nelfinavir, Novobiocin, Nystatin, Paritaprevir, Pexidartinib, Pibrentasvir, Pioglitazone, Remdesivir, Rifampicin, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rucaparib, Sacubitril, Selinexor, Silibinin, Simeprevir, Sulfasalazine, Telithromycin, Tipranavir, Ubrogepant, Velpatasvir, Vincristine, Voxilaprevir
3Solute carrier organic anion transporter family member 1B3 transportersVelpatasvir
4Solute carrier organic anion transporter family member 1B3 inducersClotrimazole, Progesterone
Interacting GroupInteracting Drugs
Valspodar is a P-glycoprotein 1 inhibitor
1P-glycoprotein 1 inducersAcetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Atazanavir, Beclomethasone dipropionate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Darunavir, Daunorubicin, Dexamethasone, Diclofenac, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Hydrocortisone, Indinavir, Ivermectin, Levothyroxine, Liothyronine, Liotrix, Lopinavir, Lumacaftor, Methylprednisolone, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Phenobarbital, Platelet Activating Factor, Prednisolone phosphate, Prednisone, Progesterone, Propofol, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Tipranavir, Trazodone, Vinblastine, Vincristine
2P-glycoprotein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Axitinib, Azelastine, Azithromycin, Benzocaine, Bepridil, Bicalutamide, Biricodar, Bisoprolol, Boceprevir, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carfilzomib, Carvedilol, Caspofungin, Ceftriaxone, Cethromycin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Conivaptan, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elacridar, Elagolix, Elbasvir, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Esomeprazole, Estramustine, Etoposide, Favipiravir, Fedratinib, Felodipine, Fentanyl, Fingolimod, Flibanserin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Galantamine, Gallopamil, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Istradefylline, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ketoconazole, Lamotrigine, Laniquidar, Lansoprazole, Lapatinib, Lasmiditan, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lonafarnib, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Methylene blue, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Mitotane, Mitoxantrone, Naproxen, Nefazodone, Nelfinavir, Neratinib, Netupitant, Nicardipine, Niguldipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Norethisterone, Norgestimate, Olaparib, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pemigatinib, Pibrentasvir, Pimozide, Piperine, Polyethylene glycol, Polyethylene glycol 400, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Salinomycin, Saquinavir, Sarecycline, Scopolamine, Selegiline, Selpercatinib, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Tariquidar, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tipifarnib, Tipranavir, Tolvaptan, Trifluoperazine, Triflupromazine, Troleandomycin, Upadacitinib, Valinomycin, Vandetanib, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine, Zonisamide, Zosuquidar
3P-glycoprotein 1 substratesAbemaciclib, Acebutolol, Acenocoumarol, Acetaminophen, Acetylsalicylic acid, Afatinib, Albendazole, Aldosterone, Alectinib, Aliskiren, Alitretinoin, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Arsenic trioxide, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Avatrombopag, Axitinib, Azathioprine, Azithromycin, Baricitinib, Beclomethasone dipropionate, Belinostat, Betamethasone, Betrixaban, Bisoprolol, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Camptothecin, Canagliflozin, Capmatinib, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cethromycin, Cetirizine, Chloramphenicol succinate, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Daclatasvir, Dacomitinib, Dactinomycin, Dapagliflozin, Darolutamide, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Empagliflozin, Enasidenib, Enfortumab vedotin, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Everolimus, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Flecainide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Gramicidin D, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Hydroxyzine, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ixabepilone, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Larotrectinib, Lasmiditan, Ledipasvir, Lefamulin, Lemborexant, Lenalidomide, Lenvatinib, Letermovir, Letrozole, Levamlodipine, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Loratadine, Losartan, Lusutrombopag, Medrysone, Mefloquine, Meperidine, Methotrexate, Methylene blue, Methylprednisolone, Metoclopramide, Mibefradil, Mirabegron, Mitoxantrone, Monensin, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Nortriptyline, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Osimertinib, Oxcarbazepine, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Pemigatinib, Pentazocine, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Platelet Activating Factor, Pomalidomide, Ponatinib, Posaconazole, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Remdesivir, Reserpine, Revefenacin, Rhodamine 6G, Rifamycin, Rimegepant, Ripretinib, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Selpercatinib, Selumetinib, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Talinolol, Tamoxifen, Taurocholic acid, Tazemetostat, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tipranavir, Tolvaptan, Topiramate, Topotecan, Toremifene, Trastuzumab deruxtecan, Trastuzumab emtansine, Trimethoprim, Trimipramine, Tucatinib, Ubidecarenone, Ubrogepant, Umeclidinium, Upadacitinib, Valinomycin, Vardenafil, Vecuronium, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vismodegib, Voxilaprevir, Zanubrutinib, Zidovudine
4P-glycoprotein 1 modulatorsAcetylsalicylic acid, Avapritinib, Prazosin
5P-glycoprotein 1 transportersLedipasvir, Tocopherol
6P-glycoprotein 1 bindersTechnetium Tc-99m tetrofosmin
7P-glycoprotein 1 antagonistsTocofersolan