Showing BioInteractions for Mitoxantrone (DB01204)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.
Interacting GroupInteracting Drugs
Mitoxantrone is a Cytochrome P450 2E1 substrate
1Cytochrome P450 2E1 substrates1,2-dichlorobenzene, Acetaminophen, Almotriptan, Aminophylline, Aniline, Antipyrine, Benzyl alcohol, Bupropion, Caffeine, Capsaicin, Carvedilol, Chlorzoxazone, Clevidipine, Dacarbazine, Dalfampridine, Dapsone, Dexloxiglumide, Dexmedetomidine, Dichlorobenzene, Enflurane, Enfuvirtide, Estrone, Ethanol, Ethosuximide, Etoposide, Felbamate, Fingolimod, Fomepizole, GTS-21, Halothane, Iloperidone, Isoflurane, Isoniazid, Methoxyflurane, Mexiletine, N-Methyl-N-(Methylbenzyl)Formamide, N,N-dimethylformamide, Nicardipine, Nicotinamide, Nicotine, Nilvadipine, Ondansetron, Paramethadione, Phenacetin, Phenobarbital, Plitidepsin, Propacetamol, Quinidine, Quinine, Sevoflurane, Sildenafil, Tamoxifen, Tegafur, Thalidomide, Theobromine, Theophylline, Thiamylal, Tirapazamine, Trabectedin, Trimethadione, Zopiclone
2Cytochrome P450 2E1 inhibitorsAdemetionine, Aldesleukin, Alosetron, Azelastine, Bifonazole, Bromazepam, Chlorpromazine, Chlorzoxazone, Cimetidine, Clonazepam, Clotrimazole, Desipramine, Dexfenfluramine, Diacerein, Diazepam, Diclofenac, Diethylstilbestrol, Disulfiram, Ditiocarb, Econazole, Ellagic acid, Etoricoxib, Flunitrazepam, Fluphenazine, Flurazepam, Imipramine, Indisulam, Isoniazid, Isosorbide dinitrate, Itraconazole, Methimazole, Methotrimeprazine, Metyrapone, Miconazole, Midostaurin, Nabilone, Niacin, Nicotinamide, Nicotine, Nifedipine, Nitrazepam, Nortriptyline, Orphenadrine, Propofol, Rhein, Ritonavir, Rufinamide, Safinamide, Selegiline, Sildenafil, Sulfanilamide, Tegaserod, Thioridazine, Ticlopidine, Tioconazole, Tranylcypromine, Ursodeoxycholic acid, Vayarin, Zafirlukast, Zucapsaicin
3Cytochrome P450 2E1 inducersClofibrate, Colchicine, Delafloxacin, Dexamethasone, Ethanol, Fomepizole, Glycerin, Isoniazid, Nicotine, Phenelzine, Phenobarbital, Piperaquine, Rifampicin, Streptozocin, Ursodeoxycholic acid
Interacting GroupInteracting Drugs
Mitoxantrone is a Cytochrome P450 2E1 inducer
1Cytochrome P450 2E1 substrates1,2-dichlorobenzene, Acetaminophen, Almotriptan, Aminophylline, Aniline, Antipyrine, Benzyl alcohol, Bupropion, Caffeine, Capsaicin, Carvedilol, Chlorzoxazone, Clevidipine, Dacarbazine, Dalfampridine, Dapsone, Dexloxiglumide, Dexmedetomidine, Dichlorobenzene, Enflurane, Enfuvirtide, Estrone, Ethanol, Ethosuximide, Etoposide, Felbamate, Fingolimod, Fomepizole, GTS-21, Halothane, Iloperidone, Isoflurane, Isoniazid, Methoxyflurane, Mexiletine, N-Methyl-N-(Methylbenzyl)Formamide, N,N-dimethylformamide, Nicardipine, Nicotinamide, Nicotine, Nilvadipine, Ondansetron, Paramethadione, Phenacetin, Phenobarbital, Plitidepsin, Propacetamol, Quinidine, Quinine, Sevoflurane, Sildenafil, Tamoxifen, Tegafur, Thalidomide, Theobromine, Theophylline, Thiamylal, Tirapazamine, Trabectedin, Trimethadione, Zopiclone
2Cytochrome P450 2E1 inhibitorsAdemetionine, Aldesleukin, Alosetron, Azelastine, Bifonazole, Bromazepam, Chlorpromazine, Chlorzoxazone, Cimetidine, Clonazepam, Clotrimazole, Desipramine, Dexfenfluramine, Diacerein, Diazepam, Diclofenac, Diethylstilbestrol, Disulfiram, Ditiocarb, Econazole, Ellagic acid, Etoricoxib, Flunitrazepam, Fluphenazine, Flurazepam, Imipramine, Indisulam, Isoniazid, Isosorbide dinitrate, Itraconazole, Methimazole, Methotrimeprazine, Metyrapone, Miconazole, Midostaurin, Nabilone, Niacin, Nicotinamide, Nicotine, Nifedipine, Nitrazepam, Nortriptyline, Orphenadrine, Propofol, Rhein, Ritonavir, Rufinamide, Safinamide, Selegiline, Sildenafil, Sulfanilamide, Tegaserod, Thioridazine, Ticlopidine, Tioconazole, Tranylcypromine, Ursodeoxycholic acid, Vayarin, Zafirlukast, Zucapsaicin
3Cytochrome P450 2E1 inducersClofibrate, Colchicine, Delafloxacin, Dexamethasone, Ethanol, Fomepizole, Glycerin, Isoniazid, Nicotine, Phenelzine, Phenobarbital, Piperaquine, Rifampicin, Streptozocin, Ursodeoxycholic acid
Interacting GroupInteracting Drugs
Mitoxantrone is a Cytochrome P450 1B1 inhibitor
1Cytochrome P450 1B1 substratesAmodiaquine, Caffeine, Dasatinib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flutamide, Melatonin, Progesterone, Tamoxifen, Testosterone, Testosterone undecanoate, Theophylline, Triclabendazole
2Cytochrome P450 1B1 inhibitorsCannabidiol, Daunorubicin, Doxorubicin, Ketoconazole, Medical Cannabis, Melatonin, Nabiximols, Paclitaxel, Propofol, Resveratrol, Tamoxifen
3Cytochrome P450 1B1 inducersBiotin, Doxorubicin, Lansoprazole, Omeprazole, Primaquine, Triclocarban
4Cytochrome P450 1B1 bindersDocetaxel
Interacting GroupInteracting Drugs
Mitoxantrone is a Cytochrome P450 3A4 inhibitor
1Cytochrome P450 3A4 substrates(R)-warfarin, (S)-Warfarin, 3,5-diiodothyropropionic acid, 4-hydroxycoumarin, 5-androstenedione, 6-O-benzylguanine, 7-ethyl-10-hydroxycamptothecin, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Almotriptan, Alogliptin, Alosetron, Alpelisib, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Artesunate, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Axitinib, Azelastine, Azelnidipine, Azimilide, Azithromycin, Balaglitazone, Baloxavir marboxil, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Bencyclane, Benidipine, Benzodiazepine, Benzphetamine, Bepridil, Betamethasone, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bimatoprost, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromocriptine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Buspirone, Busulfan, Butyrfentanyl, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calanolide A, Calcitriol, Canagliflozin, Cannabidiol, Capravirine, Carbamazepine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Ceritinib, Cerivastatin, Cevimeline, Chenodeoxycholic acid, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clorindione, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desipramine, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexloxiglumide, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Doxycycline, Dronabinol, Dronedarone, Drospirenone, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Elvitegravir, Emopamil, Enasidenib, Encorafenib, Entrectinib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Erdafitinib, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esketamine, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Fedratinib, Felbamate, Felodipine, Fendiline, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Flucloxacillin, Fludrocortisone, Fluindione, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Fluprednisolone acetate, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fulvestrant, Fusidic acid, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxychloroquine, Hydroxyprogesterone, Hydroxyprogesterone caproate, Ibrutinib, Ibuprofen, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Irinotecan, Isavuconazole, Isavuconazonium, Isotretinoin, Isradipine, Istradefylline, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lefamulin, Lenvatinib, Lercanidipine, Letrozole, Leuprolide, Levacetylmethadol, Levamlodipine, Levobupivacaine, Levocetirizine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Metoclopramide, Metoprolol, Mexazolam, Mexiletine, Mianserin, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osimertinib, Ospemifene, Otilonium, Oxybutynin, Oxycodone, Oxymorphone, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Paroxetine, Pazopanib, Penfluridol, Perampanel, Pergolide, Perhexiline, Perospirone, Perphenazine, Pexidartinib, Phenacetin, Phenprocoumon, Phentermine, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Plitidepsin, Polatuzumab vedotin, Pomalidomide, Ponatinib, Posaconazole, Pranlukast, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisone, Prednylidene, Pregnenolone, Prenylamine, Pretomanid, Primaquine, Progesterone, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifalazil, Rifapentine, Rifaximin, Rilpivirine, Rimexolone, Rimonabant, Riociguat, Risperidone, Ritonavir, Rivaroxaban, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropivacaine, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Selinexor, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Siponimod, Sirolimus, Sitagliptin, Solifenacin, Sonidegib, Sorafenib, St. John's Wort, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Tenapanor, Teniposide, Tenofovir, Tenofovir alafenamide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Tinidazole, Tiotropium, Tipranavir, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Topiramate, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Triclabendazole, Trifarotene, Trilostane, Trimebutine, Trimethadione, Trimethoprim, Troleandomycin, Udenafil, Ulipristal, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vitamin E, Vorapaxar, Voriconazole, Vortioxetine, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zaleplon, Ziconotide, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2Cytochrome P450 3A4 inducersAcetaminophen, Amcinonide, Aminoglutethimide, Amprenavir, Apalutamide, Aprepitant, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cerivastatin, Chlorphenesin, Chlorpromazine, Clevidipine, Clobetasol, Clobetasol propionate, Clocortolone acetate, Clofazimine, Clofibrate, Cloprednol, Clotrimazole, Clozapine, Corticotropin, Cortisone, Cortisone acetate, Cortivazol, Cyclophosphamide, Cyclosporine, Dabrafenib, Deferasirox, Deflazacort, Delafloxacin, Desonide, Dexamethasone, Dexamethasone isonicotinate, Dicloxacillin, Difluocortolone, Efavirenz, Enasidenib, Enzalutamide, Esketamine, Eslicarbazepine, Eslicarbazepine acetate, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Halometasone, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivermectin, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Medrysone, Melengestrol acetate, Meperidine, Meprednisone, Metamizole, Methadone, Methylprednisolone, Methylprednisolone hemisuccinate, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Mometasone, Mometasone furoate, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Paramethasone, Pegvisomant, Pentobarbital, Perampanel, Pexidartinib, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Primidone, Probenecid, Progesterone, Propacetamol, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Ritonavir, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamylal, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine, Vitamin E, Warfarin
3Cytochrome P450 3A4 inhibitors6-Deoxyerythronolide B, 7-ethyl-10-hydroxycamptothecin, Abemaciclib, Abiraterone, Acalabrutinib, Acetazolamide, Aldesleukin, Amiodarone, Amlodipine, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, AVE9633, Azelastine, Barnidipine, Benidipine, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Caspofungin, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clofazimine, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Curcumin sulfate, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desvenlafaxine, Dexamethasone, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diclofenac, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Ditiocarb, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Econazole, Edetate disodium anhydrous, Efavirenz, Efonidipine, Elbasvir, Elexacaftor, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergotamine, Erlotinib, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Glyburide, GPI-1485, Haloperidol, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isoniazid, Isradipine, Itraconazole, Ivacaftor, Ixabepilone, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levofloxacin, Levosalbutamol, Linagliptin, Lomustine, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Medical Cannabis, Mefloquine, Mepartricin, Mequitazine, Methadone, Methimazole, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab Soravtansine, Mitemcinal, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitric Oxide, Norfloxacin, Noscapine, Nystatin, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Orphenadrine, Osimertinib, Oxcarbazepine, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Pexidartinib, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Piperine, Posaconazole, Primaquine, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Remacemide, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Ritonavir, Rokitamycin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Salbutamol, Saquinavir, Saracatinib, Sarilumab, Selamectin, Seproxetine, Sertraline, Simeprevir, Simvastatin, Sitaxentan, Solithromycin, Somatostatin, Sorafenib, Stiripentol, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tofisopam, Topiroxostat, Topotecan, Toremifene, Trastuzumab emtansine, Triclabendazole, Troleandomycin, Tylosin, Tylvalosin, Valproic acid, Vapreotide, Venetoclax, Verapamil, Vinblastine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine
Interacting GroupInteracting Drugs
Mitoxantrone is a P-glycoprotein 1 substrate
1P-glycoprotein 1 inducersAcetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Beclomethasone dipropionate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Mifepristone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2P-glycoprotein 1 substratesAbemaciclib, Acebutolol, Acenocoumarol, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Alpelisib, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Arsenic trioxide, Asunaprevir, Atazanavir, Atorvastatin, Avatrombopag, Axitinib, Azithromycin, Beclomethasone dipropionate, Belinostat, Betamethasone, Betrixaban, Bisoprolol, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Camptothecin, Canagliflozin, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cetirizine, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dacomitinib, Dactinomycin, Dapagliflozin, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Donepezil, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Flecainide, Fluciclovine (18F), Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lasmiditan, Ledipasvir, Lefamulin, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Loratadine, Losartan, Lusutrombopag, Mannitol, Methotrexate, Methylprednisolone, Metoclopramide, Metoprolol, Mirabegron, Morphine, Moxidectin, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Osimertinib, Oxcarbazepine, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Reserpine, Revefenacin, Rifamycin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Tamoxifen, Taurocholic acid, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Tramadol, Trastuzumab emtansine, Trimipramine, Ubidecarenone, Umeclidinium, Vardenafil, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Vismodegib, Voxilaprevir, Zidovudine
3P-glycoprotein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Azelastine, Azithromycin, Benzocaine, Bepridil, Bisoprolol, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carvedilol, Caspofungin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erythromycin, Esomeprazole, Estramustine, Etoposide, Fedratinib, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Istradefylline, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ketoconazole, Lansoprazole, Lapatinib, Lasmiditan, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Lusutrombopag, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Naproxen, Nefazodone, Nelfinavir, Neratinib, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pibrentasvir, Pimozide, Piperine, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Sarecycline, Scopolamine, Selegiline, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Troleandomycin, Vardenafil, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine
4P-glycoprotein 1 modulatorsAcetylsalicylic acid, Prazosin
5P-glycoprotein 1 transportersLedipasvir, Tocopherol
6P-glycoprotein 1 bindersTechnetium Tc-99m tetrofosmin
7P-glycoprotein 1 antagonistsTocofersolan
Interacting GroupInteracting Drugs
Mitoxantrone is a P-glycoprotein 1 inhibitor
1P-glycoprotein 1 inducersAcetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Beclomethasone dipropionate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Mifepristone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2P-glycoprotein 1 substratesAbemaciclib, Acebutolol, Acenocoumarol, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Alpelisib, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Arsenic trioxide, Asunaprevir, Atazanavir, Atorvastatin, Avatrombopag, Axitinib, Azithromycin, Beclomethasone dipropionate, Belinostat, Betamethasone, Betrixaban, Bisoprolol, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Camptothecin, Canagliflozin, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cetirizine, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dacomitinib, Dactinomycin, Dapagliflozin, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Donepezil, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Flecainide, Fluciclovine (18F), Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lasmiditan, Ledipasvir, Lefamulin, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Loratadine, Losartan, Lusutrombopag, Mannitol, Methotrexate, Methylprednisolone, Metoclopramide, Metoprolol, Mirabegron, Morphine, Moxidectin, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Osimertinib, Oxcarbazepine, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Reserpine, Revefenacin, Rifamycin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Tamoxifen, Taurocholic acid, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Tramadol, Trastuzumab emtansine, Trimipramine, Ubidecarenone, Umeclidinium, Vardenafil, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Vismodegib, Voxilaprevir, Zidovudine
3P-glycoprotein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Azelastine, Azithromycin, Benzocaine, Bepridil, Bisoprolol, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carvedilol, Caspofungin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erythromycin, Esomeprazole, Estramustine, Etoposide, Fedratinib, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Istradefylline, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ketoconazole, Lansoprazole, Lapatinib, Lasmiditan, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Lusutrombopag, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Naproxen, Nefazodone, Nelfinavir, Neratinib, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pibrentasvir, Pimozide, Piperine, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Sarecycline, Scopolamine, Selegiline, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Troleandomycin, Vardenafil, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine
4P-glycoprotein 1 modulatorsAcetylsalicylic acid, Prazosin
5P-glycoprotein 1 transportersLedipasvir, Tocopherol
6P-glycoprotein 1 bindersTechnetium Tc-99m tetrofosmin
7P-glycoprotein 1 antagonistsTocofersolan
Interacting GroupInteracting Drugs
Mitoxantrone is a P-glycoprotein 1 inducer
1P-glycoprotein 1 inducersAcetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Beclomethasone dipropionate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Cyclosporine, Daunorubicin, Dexamethasone, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Indinavir, Levothyroxine, Liothyronine, Liotrix, Lumacaftor, Mifepristone, Nefazodone, Nelfinavir, Nifedipine, Norethisterone, Phenobarbital, Platelet Activating Factor, Progesterone, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Trazodone, Trimethoprim, Verapamil, Vinblastine, Vincristine
2P-glycoprotein 1 substratesAbemaciclib, Acebutolol, Acenocoumarol, Acetylsalicylic acid, Afatinib, Aldosterone, Alitretinoin, Alpelisib, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Arsenic trioxide, Asunaprevir, Atazanavir, Atorvastatin, Avatrombopag, Axitinib, Azithromycin, Beclomethasone dipropionate, Belinostat, Betamethasone, Betrixaban, Bisoprolol, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Camptothecin, Canagliflozin, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cetirizine, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Cisplatin, Citalopram, Clarithromycin, Clobazam, Clomifene, Clonidine, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Dacomitinib, Dactinomycin, Dapagliflozin, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Donepezil, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Flecainide, Fluciclovine (18F), Fluticasone, Fluticasone furoate, Fluticasone propionate, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Lasmiditan, Ledipasvir, Lefamulin, Lenalidomide, Lenvatinib, Letermovir, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Loperamide, Loratadine, Losartan, Lusutrombopag, Mannitol, Methotrexate, Methylprednisolone, Metoclopramide, Metoprolol, Mirabegron, Morphine, Moxidectin, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Osimertinib, Oxcarbazepine, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Pomalidomide, Ponatinib, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Reserpine, Revefenacin, Rifamycin, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Tamoxifen, Taurocholic acid, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tolvaptan, Topotecan, Toremifene, Tramadol, Trastuzumab emtansine, Trimipramine, Ubidecarenone, Umeclidinium, Vardenafil, Vecuronium, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Vinflunine, Vinorelbine, Vismodegib, Voxilaprevir, Zidovudine
3P-glycoprotein 1 inhibitorsAbemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Azelastine, Azithromycin, Benzocaine, Bepridil, Bisoprolol, Boceprevir, Bosutinib, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carvedilol, Caspofungin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erythromycin, Esomeprazole, Estramustine, Etoposide, Fedratinib, Felodipine, Fentanyl, Fexofenadine, Fidaxomicin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Istradefylline, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ketoconazole, Lansoprazole, Lapatinib, Lasmiditan, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Lusutrombopag, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Naproxen, Nefazodone, Nelfinavir, Neratinib, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pibrentasvir, Pimozide, Piperine, Ponatinib, Posaconazole, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Saquinavir, Sarecycline, Scopolamine, Selegiline, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tolvaptan, Trifluoperazine, Triflupromazine, Trimethoprim, Troleandomycin, Vardenafil, Velpatasvir, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine
4P-glycoprotein 1 modulatorsAcetylsalicylic acid, Prazosin
5P-glycoprotein 1 transportersLedipasvir, Tocopherol
6P-glycoprotein 1 bindersTechnetium Tc-99m tetrofosmin
7P-glycoprotein 1 antagonistsTocofersolan
Interacting GroupInteracting Drugs
Mitoxantrone is a Multidrug resistance-associated protein 1 substrate
1Multidrug resistance-associated protein 1 inhibitorsAbiraterone, Amprenavir, Atazanavir, Cannabidiol, Conjugated estrogens, Daunorubicin, Diclofenac, Doxorubicin, Etoposide, Genistein, Glutathione, Glyburide, Ibuprofen, Idarubicin, Indinavir, Indomethacin, Ivermectin, Lamivudine, Medical Cannabis, Methotrexate, Mifepristone, Myricetin, Nabiximols, Naringenin, Ofloxacin, Paclitaxel, Probenecid, Progesterone, Quercetin, Rifampicin, Ritonavir, Sulfinpyrazone, Taurocholic acid, Vandetanib, Vemurafenib, Verapamil, Vinblastine, Vincristine
2Multidrug resistance-associated protein 1 inducersCholic Acid, Phenobarbital, Quercetin, Ritonavir, Taurocholic acid, Vinblastine
3Multidrug resistance-associated protein 1 substratesAcemetacin, Aminohippuric acid, Atazanavir, Atorvastatin, Dactinomycin, Daunorubicin, Docetaxel, Doxorubicin, Epirubicin, Etoposide, Fluorescein, Glutathione, Grepafloxacin, Irinotecan, Methotrexate, Rhodamine 6G, Saquinavir, Saxagliptin, Technetium Tc-99m sestamibi, Vemurafenib, Vinblastine, Vincristine, Zoledronic acid
Interacting GroupInteracting Drugs
Mitoxantrone is a Multidrug resistance-associated protein 1 inhibitor
1Multidrug resistance-associated protein 1 inhibitorsAbiraterone, Amprenavir, Atazanavir, Cannabidiol, Conjugated estrogens, Daunorubicin, Diclofenac, Doxorubicin, Etoposide, Genistein, Glutathione, Glyburide, Ibuprofen, Idarubicin, Indinavir, Indomethacin, Ivermectin, Lamivudine, Medical Cannabis, Methotrexate, Mifepristone, Myricetin, Nabiximols, Naringenin, Ofloxacin, Paclitaxel, Probenecid, Progesterone, Quercetin, Rifampicin, Ritonavir, Sulfinpyrazone, Taurocholic acid, Vandetanib, Vemurafenib, Verapamil, Vinblastine, Vincristine
2Multidrug resistance-associated protein 1 inducersCholic Acid, Phenobarbital, Quercetin, Ritonavir, Taurocholic acid, Vinblastine
3Multidrug resistance-associated protein 1 substratesAcemetacin, Aminohippuric acid, Atazanavir, Atorvastatin, Dactinomycin, Daunorubicin, Docetaxel, Doxorubicin, Epirubicin, Etoposide, Fluorescein, Glutathione, Grepafloxacin, Irinotecan, Methotrexate, Rhodamine 6G, Saquinavir, Saxagliptin, Technetium Tc-99m sestamibi, Vemurafenib, Vinblastine, Vincristine, Zoledronic acid
Interacting GroupInteracting Drugs
Mitoxantrone is a ATP-binding cassette sub-family G member 2 substrate
1ATP-binding cassette sub-family G member 2 substratesAbemaciclib, Afatinib, Allopurinol, Alpelisib, Alvocidib, Apixaban, Baricitinib, Brigatinib, Camptothecin, Carboplatin, Celecoxib, Cerivastatin, Cisplatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dacomitinib, Dactinomycin, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Dolutegravir, Donepezil, Doxorubicin, Duvelisib, Enasidenib, Ertugliflozin, Etoposide, Ezetimibe, Fimasartan, Fluorouracil, Folic acid, Gefitinib, Glasdegib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Leflunomide, Lenvatinib, Lusutrombopag, Methotrexate, Moxidectin, Mycophenolate mofetil, Nilotinib, Nitrofurantoin, Ombitasvir, Osimertinib, Oxaliplatin, Palbociclib, Pantoprazole, Pazopanib, Pibrentasvir, Pitavastatin, Ponatinib, Pravastatin, Prazosin, Raloxifene, Revefenacin, Riluzole, Riociguat, Rivaroxaban, Rosuvastatin, Rucaparib, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sumatriptan, Talazoparib, Tamoxifen, Tegaserod, Teniposide, Tenofovir alafenamide, Teriflunomide, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Topotecan, Velpatasvir, Vemurafenib, Vincristine, Voxilaprevir, Zidovudine
2ATP-binding cassette sub-family G member 2 inhibitorsAbemaciclib, Afatinib, Alectinib, Avatrombopag, Baricitinib, Beclomethasone dipropionate, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Cannabidiol, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Dacomitinib, Daidzin, Dasabuvir, Dasatinib, Dexamethasone, Diethylstilbestrol, Dovitinib, Dronabinol, Elacridar, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Fedratinib, Fostamatinib, Fusidic acid, Gefitinib, Genistein, Gilteritinib, Glasdegib, Glecaprevir, Hesperetin, Imatinib, Isavuconazole, Istradefylline, Lansoprazole, Lasmiditan, Letermovir, Medical Cannabis, Nabiximols, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Olaparib, Omeprazole, Palbociclib, Pantoprazole, Paritaprevir, Pibrentasvir, Ponatinib, Progesterone, Quercetin, Rabeprazole, Regorafenib, Rilpivirine, Ritonavir, Rolapitant, Rucaparib, Safinamide, Saquinavir, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Taurocholic acid, Telmisartan, Teriflunomide, Topiroxostat, Vandetanib, Velpatasvir, Vemurafenib, Venetoclax, Verapamil, Vismodegib, Voxilaprevir
3ATP-binding cassette sub-family G member 2 inducersApalutamide, Cholesterol, Dovitinib, Estradiol, Progesterone, Venlafaxine
4ATP-binding cassette sub-family G member 2 antagonistsZafirlukast
5ATP-binding cassette sub-family G member 2 weak inhibitorsCobimetinib
6ATP-binding cassette sub-family G member 2 transportersLedipasvir