Showing BioInteractions for Istradefylline (DB11757)

BioInteractor utilizes data on drug-target, -enzyme and -transporter associations to provide insight on drug-drug interactions. It allows you to identify, for instance, which drugs act similarly on the same target. Such drugs may have additive pharmacodynamic effects if given concomitantly. Conversely, two drugs may antagonize the beneficial effects of each other by having opposite actions on a specific drug target. BioInteractor uses ranked drug-enzyme association information to predict enzyme-mediated drug interactions that may be clinically relevant.

	Interacting Group	Interacting Drugs
	Istradefylline is a Adenosine receptor A2a antagonist
1	Adenosine receptor A2a antagonists	8-chlorotheophylline, Caffeine, Doxofylline, Dyphylline, Mefloquine, Oxtriphylline, Pentoxifylline, Theobromine, Theophylline
2	Adenosine receptor A2a agonists	Adenosine, Regadenoson
3	Adenosine receptor A2a inhibitors	Enprofylline, Lamotrigine

	Interacting Group	Interacting Drugs
	Istradefylline is a Adenosine receptor A1 antagonist
1	Adenosine receptor A1 antagonists	Aminophylline, Caffeine, Dyphylline, Naxifylline, Oxtriphylline, Pentoxifylline, Theobromine, Theophylline
2	Adenosine receptor A1 agonists	Adenosine, Gabapentin
3	Adenosine receptor A1 inhibitors	Enprofylline, Lamotrigine
4	Adenosine receptor A1 activators	Cannabidiol
5	Adenosine receptor A1 stimulators	Tramadol

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 1A1 substrate
1	Cytochrome P450 1A1 substrates	(R)-warfarin, Amiodarone, Amodiaquine, Azelastine, Azimilide, Banoxantrone, Carvedilol, Chloroquine, Chlorzoxazone, Cinnarizine, Clenbuterol, Clonidine, Copanlisib, Dacarbazine, Dapagliflozin, Dasatinib, Daunorubicin, Debrisoquine, Difloxacin, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Flunarizine, Flutamide, Fluvastatin, Gefitinib, Granisetron, Haloperidol, Indirubin, Loratadine, Lorcaserin, Melatonin, Nicotine, Omeprazole, Pentamidine, Perospirone, Phenacetin, Pioglitazone, Progesterone, Resveratrol, Riluzole, Riociguat, Risdiplam, Romidepsin, Solifenacin, Tamoxifen, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Theophylline, Toremifene, Tretinoin, Triclabendazole
2	Cytochrome P450 1A1 inhibitors	Amlodipine, Azelastine, Benzyl alcohol, Caffeine, Cannabidiol, Cholecalciferol, Dexamethasone, Dexamethasone acetate, Dexmedetomidine, Ellagic acid, Ethanol, Fluvoxamine, Gefitinib, Isoprenaline, Ketoconazole, Manidipine, Medical Cannabis, Melatonin, Menadione, Methoxsalen, Nabiximols, Nifedipine, Nitroprusside, Norfloxacin, Propofol, Propranolol, Pyridoxine, Quinidine, Quinine, Resveratrol, Safinamide, Sulindac, Theophylline, Topiroxostat
3	Cytochrome P450 1A1 inducers	Albendazole, Bezafibrate, Clofibrate, Clozapine, Dexamethasone, Dexamethasone acetate, Dovitinib, Ellagic acid, Fluvastatin, Itraconazole, Ketoconazole, Lansoprazole, Mebendazole, Menadione, Nicotine, Omeprazole, Phenobarbital, Picrotoxin, Primaquine, Propylthiouracil, Quinine, Rabeprazole, Streptozocin, Thiabendazole, Triclocarban, Troglitazone

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 3A4 substrate
1	Cytochrome P450 3A4 substrates	(R)-warfarin, (S)-Warfarin, 1,2-Benzodiazepine, 3,5-diiodothyropropionic acid, 5-androstenedione, 6-O-benzylguanine, 9-aminocamptothecin, Abemaciclib, Abiraterone, Acalabrutinib, Acenocoumarol, Acetaminophen, Adinazolam, Agmatine, Albendazole, Alclometasone, Aldosterone, Alfentanil, Alfuzosin, Aliskiren, Almotriptan, Alogliptin, Alosetron, Alpelisib, alpha-Tocopherol acetate, Alprazolam, Ambrisentan, Ambroxol, Amcinonide, Aminophenazone, Aminophylline, Amiodarone, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Androstenedione, Antipyrine, Apalutamide, Apixaban, Apremilast, Aprepitant, Aranidipine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Asenapine, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Avanafil, Avapritinib, Axitinib, Azelastine, Azelnidipine, Azimilide, Azithromycin, Balaglitazone, Baloxavir marboxil, Banoxantrone, Baricitinib, Barnidipine, Beclomethasone dipropionate, Bedaquiline, Belinostat, Bencyclane, Benidipine, Benzphetamine, Bepridil, Betamethasone, Betamethasone phosphate, Bexarotene, Bezafibrate, Bicalutamide, Bictegravir, Bimatoprost, Bioallethrin, Bisoprolol, Blonanserin, Boceprevir, Bortezomib, Bosentan, Bosutinib, Brentuximab vedotin, Brexpiprazole, Brigatinib, Brinzolamide, Brivaracetam, Bromocriptine, Brotizolam, Budesonide, Bupivacaine, Buprenorphine, Buspirone, Busulfan, Butyrfentanyl, Cabazitaxel, Cabergoline, Cabozantinib, Caffeine, Calanolide A, Calcitriol, Canagliflozin, Cannabidiol, Capmatinib, Capravirine, Carbamazepine, Carboxyamidotriazole, Cariprazine, Caroverine, Carvedilol, Celecoxib, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Cevimeline, Chenodeoxycholic acid, Chlormadinone, Chloroquine, Chlorpheniramine, Chlorzoxazone, Cholecalciferol, Ciclesonide, Ciglitazone, Cilnidipine, Cilostazol, Cinacalcet, Cinnarizine, Cisapride, Citalopram, Clarithromycin, Clevidipine, Clindamycin, Clobazam, Clobetasol, Clobetasol propionate, Clobetasone, Clofibrate, Clomethiazole, Clomipramine, Clonazepam, Clonidine, Clopidogrel, Clorazepic acid, Clotiazepam, Clotrimazole, Clozapine, Cobicistat, Cobimetinib, Cocaine, Codeine, Colchicine, Conivaptan, Conjugated estrogens, Copanlisib, Corticosterone, Corticotropin, Cortisone acetate, Crizotinib, Cyclandelate, Cyclobenzaprine, Cyclophosphamide, Cyclosporine, Cyproterone acetate, Cytarabine, Dabrafenib, Daclatasvir, Dacomitinib, Dapagliflozin, Dapoxetine, Dapsone, Darifenacin, Darodipine, Darolutamide, Darunavir, Dasabuvir, Dasatinib, Daunorubicin, Deflazacort, Delamanid, Delavirdine, Demegestone, Desogestrel, Desonide, Desoxycorticosterone acetate, Desoxycorticosterone pivalate, Desvenlafaxine, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dexchlorpheniramine maleate, Dexlansoprazole, Dexloxiglumide, Dexniguldipine, Dextromethorphan, Dextropropoxyphene, Dexverapamil, Diazepam, Diclofenac, Dienogest, Diethylstilbestrol, Difluocortolone, Difluprednate, Digitoxin, Dihydro-alpha-ergocryptine, Dihydrocodeine, Dihydroergocornine, Dihydroergocristine, Dihydroergocryptine, Dihydroergotamine, Diltiazem, Diphenadione, Disopyramide, Disulfiram, Docetaxel, Dofetilide, Dolasetron, Domperidone, Donepezil, Doravirine, Dotarizine, Doxazosin, Doxepin, Doxorubicin, Doxycycline, Dronabinol, Dronedarone, Drospirenone, Duvelisib, Dydrogesterone, Ebastine, Efavirenz, Efonidipine, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Elvitegravir, Emopamil, Enasidenib, Encorafenib, Enfortumab vedotin, Entrectinib, Enzalutamide, Eperisone, Epinastine, Eplerenone, Equilenin, Equilin, Eravacycline, Erdafitinib, Ergoloid mesylate, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Escitalopram, Esketamine, Esomeprazole, Estazolam, Esterified estrogens, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estramustine, Estrone, Estrone sulfate, Eszopiclone, Ethanol, Ethinylestradiol, Ethosuximide, Ethyl biscoumacetate, Ethylmorphine, Ethynodiol diacetate, Etizolam, Etonogestrel, Etoposide, Etoricoxib, Etravirine, Etynodiol, Everolimus, Exemestane, Fedratinib, Felbamate, Felodipine, Fendiline, Fenfluramine, Fentanyl, Fesoterodine, Finasteride, Fish oil, Flibanserin, Flucloxacillin, Fludrocortisone, Flumethasone, Flunarizine, Flunisolide, Flunitrazepam, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluoxetine, Fluprednidene, Fluprednisolone, Fluprednisolone acetate, Flurandrenolide, Flurazepam, Fluspirilene, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fosphenytoin, Fostamatinib, Fostemsavir, Fulvestrant, Fusidic acid, Galantamine, Gallopamil, Gefitinib, Gemfibrozil, Gestodene, Gestrinone, Gilteritinib, Glasdegib, Glyburide, Granisetron, Grazoprevir, Grepafloxacin, Guanfacine, Halcinonide, Halofantrine, Haloperidol, Halothane, HE3286, Hydrocodone, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Hydroxychloroquine, Hydroxyprogesterone, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Ibuprofen, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Imidafenacin, Imipramine, Imiquimod, Indacaterol, Indalpine, Indapamide, Indinavir, Ipecac, Irinotecan, Isavuconazole, Isavuconazonium, Isotretinoin, Isradipine, Itraconazole, Ivabradine, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ixazomib, Ketamine, Ketazolam, Ketobemidone, Ketoconazole, Lacidipine, Lacosamide, Lansoprazole, Lapatinib, Laquinimod, Larotrectinib, Lefamulin, Lemborexant, Lenvatinib, Lercanidipine, Letrozole, Levacetylmethadol, Levamlodipine, Levobupivacaine, Levocetirizine, Levomenthol, Levomilnacipran, Levonorgestrel, Lidocaine, Lidoflazine, Linagliptin, Liotrix, Lisuride, Lobeglitazone, Lomerizine, Lomitapide, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorazepam, Lorcaserin, Lorpiprazole, Losartan, Loteprednol etabonate, Lovastatin, Lumefantrine, Lurasidone, Lurbinectedin, Lynestrenol, Lysergic acid diethylamide, Macimorelin, Macitentan, Manidipine, Maraviroc, Medrogestone, Medroxyprogesterone acetate, Medrysone, Mefloquine, Megestrol acetate, Melengestrol, Meloxicam, Meperidine, Meprednisone, Mestranol, Methadone, Methaqualone, Methotrexate, Methoxyflurane, Methylergometrine, Methylprednisolone, Methylprednisone, Methyltestosterone, Methysergide, Metoclopramide, Metoprolol, Mexazolam, Mexiletine, Mianserin, Mibefradil, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Mirabegron, Mirtazapine, Modafinil, Mometasone, Mometasone furoate, Montelukast, Morphine, Mycophenolate mofetil, Nabiximols, Naftopidil, Naloxegol, Nateglinide, Nebivolol, Nefazodone, Nelfinavir, Neratinib, Netoglitazone, Netupitant, Nevirapine, Nicardipine, Nicotine, Nifedipine, Niguldipine, Nilotinib, Niludipine, Nilvadipine, Nimesulide, Nimodipine, Nintedanib, Nisoldipine, Nitrazepam, Nitrendipine, Nomegestrol, Nomegestrol acetate, Norelgestromin, Norethindrone enanthate, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Nortriptyline, Nylidrin, Odanacatib, Olaparib, Oliceridine, Olopatadine, Omeprazole, Ondansetron, Opium, Orphenadrine, Osilodrostat, Osimertinib, Ospemifene, Otilonium, Oxybutynin, Oxycodone, Oxymorphone, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Palonosetron, Panobinostat, Pantoprazole, Paramethadione, Paramethasone, Parecoxib, Paricalcitol, Paritaprevir, Paroxetine, Pazopanib, Pemigatinib, Penfluridol, Perampanel, Perhexiline, Perospirone, Perphenazine, Pexidartinib, Phenacetin, Phenprocoumon, Phentermine, Phenytoin, Pimecrolimus, Pimozide, Pinacidil, Pinaverium, Pioglitazone, Piperaquine, Pipotiazine, Pitolisant, Plitidepsin, Polatuzumab vedotin, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pranlukast, Prasugrel, Prazepam, Praziquantel, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Prednylidene, Pregnenolone, Prenylamine, Pretomanid, Primaquine, Progesterone, Promazine, Promegestone, Propacetamol, Propafenone, Propiverine, Propranolol, Prucalopride, Quazepam, Quetiapine, Quinacrine, Quingestanol, Quinidine, Quinine, Rabeprazole, Ramelteon, Ranolazine, Reboxetine, Regorafenib, Remdesivir, Repaglinide, Retapamulin, Ribociclib, Rifabutin, Rifalazil, Rifapentine, Rifaximin, Rilpivirine, Rimegepant, Rimexolone, Rimonabant, Riociguat, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Rivoglitazone, Rofecoxib, Roflumilast, Rolapitant, Romidepsin, Ropivacaine, Rosiglitazone, Rotigotine, Roxithromycin, Rucaparib, Rufinamide, Rupatadine, Ruxolitinib, Safinamide, Salmeterol, Saquinavir, Saxagliptin, Segesterone acetate, Selegiline, Seletracetam, Selexipag, Selinexor, Selpercatinib, Selumetinib, Seratrodast, Sertindole, Sertraline, Sevoflurane, Sibutramine, Sildenafil, Silodosin, Simeprevir, Simvastatin, Siponimod, Sirolimus, Sitagliptin, SN-38, Solifenacin, Sonidegib, Sorafenib, St. John's Wort, Sufentanil, Sulfadiazine, Sulfamethoxazole, Sulfinpyrazone, Sunitinib, Suvorexant, Synthetic Conjugated Estrogens, A, Synthetic Conjugated Estrogens, B, Tacrolimus, Tadalafil, Tamoxifen, Tamsulosin, Tasimelteon, Tasosartan, Taurochenodeoxycholic acid, Tazemetostat, Telaprevir, Telithromycin, Temazepam, Temsirolimus, Tenapanor, Teniposide, Tenofovir, Tenofovir alafenamide, Terbinafine, Terfenadine, Terguride, Terodiline, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone propionate, Testosterone undecanoate, Tetracycline, Tetrahydropalmatine, Tetrandrine, Tezacaftor, Theophylline, Thiamylal, Thiotepa, Tiagabine, Tianeptine, Ticagrelor, Tinidazole, Tiotropium, Tipranavir, Tirbanibulin, Tocofersolan, Tocopherol, Tofacitinib, Tolfenamic acid, Tolterodine, Tolvaptan, Toremifene, Trabectedin, Tramadol, Tranilast, Trastuzumab deruxtecan, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Triclabendazole, Trifarotene, Trimebutine, Trimethadione, Trimethoprim, Troleandomycin, Ubrogepant, Udenafil, Ulipristal, Umifenovir, Upadacitinib, Valbenazine, Valdecoxib, Vandetanib, Vanoxerine, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vibegron, Vicriviroc, Vilanterol, Vilazodone, Vinblastine, Vincristine, Vindesine, Vinflunine, Vinorelbine, Vinpocetine, Vismodegib, Vitamin D, Vitamin E, Vorapaxar, Voriconazole, Vortioxetine, Voxelotor, Voxilaprevir, Warfarin, WIN 55212-2, Yohimbine, Zafirlukast, Zaleplon, Zanubrutinib, Zidovudine, Zileuton, Ziprasidone, Zolpidem, Zomepirac, Zonisamide, Zopiclone, Zotepine, Zuclopenthixol
2	Cytochrome P450 3A4 inducers	Acetaminophen, Amcinonide, Aminoglutethimide, Amprenavir, Apalutamide, Aprepitant, Aprobarbital, Armodafinil, Artemether, Asunaprevir, Avasimibe, Azatadine, Barbital, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Bexarotene, Bosentan, Budesonide, Calcitriol, Carbamazepine, Cefradine, Cenobamate, Cerivastatin, Chlorphenesin, Chlorpromazine, Clevidipine, Clobazam, Clobetasol, Clobetasol propionate, Clocortolone acetate, Clofibrate, Cloprednol, Clotrimazole, Clozapine, Corticotropin, Cortisone, Cortisone acetate, Cortivazol, Cyclophosphamide, Dabrafenib, Deferasirox, Deflazacort, Delafloxacin, Desonide, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dicloxacillin, Difluocortolone, Echinacea, Efavirenz, Enasidenib, Enzalutamide, Esketamine, Eslicarbazepine, Eslicarbazepine acetate, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Ethanol, Etoposide, Etravirine, Felbamate, Flucloxacillin, Flunisolide, Fluocinolone acetonide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Formestane, Fosaprepitant, Fosphenytoin, Genistein, Glycerol phenylbutyrate, Griseofulvin, Halometasone, Hydrocortamate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Idelalisib, Ifosfamide, Isavuconazole, Isavuconazonium, Ivermectin, Ivosidenib, Ketamine, Lansoprazole, Lenvatinib, Lesinurad, Lumacaftor, Lumefantrine, Medroxyprogesterone acetate, Medrysone, Melengestrol acetate, Meperidine, Meprednisone, Metamizole, Methadone, Methylprednisolone, Methylprednisolone hemisuccinate, Metyrapone, Midostaurin, Mifepristone, Mitotane, Modafinil, Mometasone, Mometasone furoate, Nafcillin, Nevirapine, Nifedipine, Norgestimate, Omeprazole, Oritavancin, Orlistat, Osimertinib, Oxcarbazepine, Oxiconazole, Paclitaxel, Paramethasone, Pegvisomant, Pentobarbital, Perampanel, Pexidartinib, Phenobarbital, Phenylbutazone, Phenytoin, Pioglitazone, Pitolisant, Pralsetinib, Prednicarbate, Prednisolone, Prednisolone acetate, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Primidone, Probenecid, Progesterone, Propacetamol, Quinine, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Rimexolone, Rofecoxib, Rufinamide, Sarilumab, Seratrodast, Siltuximab, St. John's Wort, Sulfinpyrazone, Tamoxifen, Terbinafine, Terfenadine, Tesmilifene, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thiamylal, Tocilizumab, Topiramate, Topotecan, Trametinib, Triamcinolone, Troglitazone, Vemurafenib, Vinblastine, Vitamin E, Warfarin
3	Cytochrome P450 3A4 inhibitors	6-Deoxyerythronolide B, Abametapir, Abemaciclib, Abiraterone, Acalabrutinib, Acetazolamide, Albuterol, Aldesleukin, Amiodarone, Amphotericin B, Amprenavir, Anastrozole, Aprepitant, Arsenic trioxide, Astemizole, Atazanavir, AVE9633, Azelastine, Azithromycin, Barnidipine, Benidipine, Berotralstat, Bicalutamide, Bifonazole, Black cohosh, Boceprevir, Bosutinib, Brefeldin A, Brentuximab vedotin, Bromocriptine, Bryostatin 1, Buprenorphine, Cabergoline, Candicidin, Capsaicin, Carbomycin, Caspofungin, Cenobamate, Ceritinib, Cerivastatin, Cethromycin, Chloramphenicol, Chlorzoxazone, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clascoterone, Clevidipine, Clindamycin, Clofazimine, Clotrimazole, Clozapine, Cobicistat, Colchicine, Coltuximab ravtansine, Conivaptan, Crizotinib, Curcumin, Curcumin sulfate, Cyclosporine, Cyproterone acetate, Dalfopristin, Danazol, Danoprevir, Dapoxetine, Darunavir, Dasatinib, Daunorubicin, Delavirdine, Desipramine, Desvenlafaxine, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Dextropropoxyphene, Diazepam, Diclofenac, Diethylstilbestrol, Dihydroergotamine, Diltiazem, Dimethyl sulfoxide, Dirithromycin, Ditiocarb, Docetaxel, Doramectin, Dovitinib, Doxorubicin, Doxycycline, Dronedarone, Econazole, Edetate calcium disodium anhydrous, Edetate disodium anhydrous, Efavirenz, Efonidipine, Elbasvir, Elexacaftor, Elvitegravir, Enasidenib, Epinephrine, Epofolate, Epothilone D, Eprinomectin, Ergotamine, Erlotinib, Erythromycin, Ethanol, Etoposide, Etoricoxib, Ezetimibe, Felodipine, Fidaxomicin, Fluconazole, Fluoxetine, Flurithromycin, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fluvoxamine, Fosamprenavir, Fosaprepitant, Fosnetupitant, Fostamatinib, Fusidic acid, Gefitinib, Ginkgo biloba, Glecaprevir, Glyburide, GPI-1485, Haloperidol, Hydralazine, Idelalisib, Ifosfamide, Imatinib, Indalpine, Indinavir, Indisulam, Irbesartan, Isavuconazole, Isavuconazonium, Isradipine, Itraconazole, Ivacaftor, Ixabepilone, Ketazolam, Ketoconazole, Kitasamycin, KOS-1584, Lanreotide, Lansoprazole, Lapatinib, Lenvatinib, Lercanidipine, Lestaurtinib, Letermovir, Levosalbutamol, Linagliptin, Lomustine, Lonafarnib, Loperamide, Lopinavir, Loratadine, Lorvotuzumab mertansine, Losartan, Lovastatin, Luliconazole, Manidipine, Medical Cannabis, Mefloquine, Mepartricin, Mequitazine, Methadone, Methimazole, Methylene blue, Methylergometrine, Metronidazole, Metyrapone, Mibefradil, Miconazole, Midazolam, Midecamycin, Midostaurin, Mifepristone, Milnacipran, Miocamycin, Mirtazapine, Mirvetuximab soravtansine, Mitemcinal, Mitoxantrone, Naloxone, Natamycin, Nefazodone, Nelfinavir, Netupitant, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nilvadipine, Nitric Oxide, Norfloxacin, Noscapine, Octreotide, Olanzapine, Olaparib, Oleandomycin, Omeprazole, Oritavancin, Orphenadrine, Osilodrostat, Osimertinib, Oxcarbazepine, Oxetacaine, Oxybutynin, Oxymetholone, Palbociclib, Paramethasone, Paroxetine, Pasireotide, Patupilone, Pazopanib, Peppermint oil, Pergolide, Pexidartinib, Phenelzine, Pilocarpine, Pimecrolimus, Pimozide, Piperaquine, Piperine, Posaconazole, Pralsetinib, Primaquine, Quinidine, Quinine, Quinupristin, Rabeprazole, Raloxifene, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Remacemide, Remdesivir, Resveratrol, Ribociclib, Ridaforolimus, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rokitamycin, Roxithromycin, Rucaparib, Rutin, Sagopilone, Saquinavir, Saracatinib, Sarilumab, Selamectin, Seproxetine, Simeprevir, Sitaxentan, SN-38, Solithromycin, Somatostatin, Sorafenib, Stiripentol, Sulfanilamide, Sunitinib, Tamoxifen, Telaprevir, Telithromycin, Teniposide, Terfenadine, Tesmilifene, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetracycline, Ticagrelor, Tildipirosin, Tilmicosin, Tioconazole, Tipranavir, Tirbanibulin, Tofisopam, Topiroxostat, Topotecan, Toremifene, Trastuzumab emtansine, Triclabendazole, Troleandomycin, Tylosin, Tylvalosin, Valproic acid, Vapreotide, Venetoclax, Verapamil, Vinblastine, Voriconazole, WIN 55212-2, Zafirlukast, Zimelidine

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 3A5 substrate
1	Cytochrome P450 3A5 substrates	Alfentanil, Alprazolam, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apomorphine, Argatroban, Aripiprazole, Aripiprazole lauroxil, Artemether, Astemizole, Asunaprevir, Atorvastatin, Axitinib, Azelastine, Azimilide, Benidipine, Bimatoprost, Boceprevir, Buprenorphine, Buspirone, Cabazitaxel, Cannabidiol, Carbamazepine, Cenobamate, Cerivastatin, Cethromycin, Chloroquine, Chlorpheniramine, Cilostazol, Cisapride, Clarithromycin, Clindamycin, Clonidine, Clopidogrel, Cobicistat, Copanlisib, Crizotinib, Cyclophosphamide, Cyclosporine, Daclatasvir, Dapsone, Dasatinib, Deutetrabenazine, Dexamethasone, Dexamethasone acetate, Dexloxiglumide, Diazepam, Diltiazem, Disulfiram, Docetaxel, Domperidone, Doravirine, Dronedarone, Dutasteride, Elbasvir, Elexacaftor, Enzalutamide, Eplerenone, Erlotinib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Ethinylestradiol, Etoposide, Felodipine, Fenfluramine, Finasteride, Fluoxetine, Flutamide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Gefitinib, Glyburide, Halofantrine, Haloperidol, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone valerate, Hydroxyprogesterone caproate, Hydroxyzine, Ibrutinib, Icotinib, Idelalisib, Ifosfamide, Iloperidone, Imatinib, Indinavir, Irinotecan, Isavuconazole, Ivacaftor, Lapatinib, Lemborexant, Lercanidipine, Levonorgestrel, Lidocaine, Lonafarnib, Loratadine, Lorlatinib, Metronidazole, Midazolam, Mifepristone, Mycophenolate mofetil, Nabiximols, Nateglinide, Nevirapine, Nifedipine, Nisoldipine, Nitrendipine, Nortriptyline, Olaparib, Ondansetron, Oxybutynin, Oxycodone, Paclitaxel, Paliperidone, Paritaprevir, Pentamidine, Perampanel, Phenytoin, Pimozide, Ponatinib, Praziquantel, Progesterone, Propranolol, Quetiapine, Quinacrine, Quinine, Ritonavir, Rivaroxaban, Romidepsin, Salmeterol, Saquinavir, Saxagliptin, Selumetinib, Sildenafil, Simvastatin, Sirolimus, Sorafenib, Sunitinib, Tacrolimus, Tadalafil, Tamoxifen, Tegafur, Temsirolimus, Tenapanor, Teniposide, Terfenadine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Trastuzumab emtansine, Trazodone, Tretinoin, Triamcinolone, Triazolam, Udenafil, Umifenovir, Valbenazine, Valproic acid, Vardenafil, Verapamil, Vicriviroc, Vincristine, Vortioxetine, Zaleplon, Zonisamide
2	Cytochrome P450 3A5 inhibitors	Acalabrutinib, Amlodipine, Boceprevir, Cannabidiol, Cenobamate, Chloramphenicol, Cimetidine, Ciprofloxacin, Clarithromycin, Clofazimine, Cobicistat, Crizotinib, Curcumin sulfate, Delavirdine, Diltiazem, Ditiocarb, Dronedarone, Elbasvir, Erythromycin, Fluconazole, Fluticasone, Fluticasone furoate, Fluticasone propionate, Gestodene, Idelalisib, Imatinib, Indinavir, Isavuconazole, Itraconazole, Ketoconazole, Letermovir, Lonafarnib, Medical Cannabis, Methylene blue, Mibefradil, Modafinil, Nabiximols, Nelfinavir, Nicardipine, Osilodrostat, Oxcarbazepine, Oxymetholone, Phenelzine, Pralsetinib, Ritonavir, Rucaparib, Safinamide, Saquinavir, Seproxetine, Temsirolimus, Troglitazone, Troleandomycin, Verapamil, Voriconazole
3	Cytochrome P450 3A5 inducers	Amcinonide, Armodafinil, Asunaprevir, Beclomethasone dipropionate, Betamethasone, Betamethasone phosphate, Budesonide, Carbamazepine, Clobetasol, Clobetasol propionate, Clocortolone acetate, Cloprednol, Cortisone, Cortisone acetate, Cortivazol, Daunorubicin, Deflazacort, Dexamethasone, Dexamethasone acetate, Dexamethasone isonicotinate, Difluocortolone, Efavirenz, Enzalutamide, Fluocinonide, Fluocortolone, Fluorometholone, Fluprednidene, Fluprednidene acetate, Fluticasone, Fluticasone furoate, Halometasone, Icotinib, Medrysone, Melengestrol acetate, Meprednisone, Methylprednisolone hemisuccinate, Midostaurin, Modafinil, Mometasone, Mometasone furoate, Oxcarbazepine, Paramethasone, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone hemisuccinate, Prednisolone phosphate, Prednisone, Prednisone acetate, Prednylidene, Reserpine, Rifampicin, Rimexolone, Thalidomide, Triamcinolone

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 1A2 substrate
1	Cytochrome P450 1A2 substrates	(R)-warfarin, 8-azaguanine, 8-chlorotheophylline, 9-Deazaguanine, 9-Methylguanine, Abametapir, Acefylline, Acenocoumarol, Acetaminophen, Agomelatine, Alosetron, Aminophenazone, Aminophylline, Amitriptyline, Anagrelide, Antipyrine, Apixaban, Apremilast, Asenapine, Axitinib, Azathioprine, Azelastine, Bamifylline, Bendamustine, Benzyl alcohol, Betaxolol, Bicifadine, Binimetinib, Bortezomib, Bromazepam, Bromotheophylline, Bufylline, Caffeine, Capsaicin, Carvedilol, Chlorpromazine, Chlorzoxazone, Cilostazol, Cinacalcet, Cinnarizine, Clomipramine, Clonidine, Clopidogrel, Clozapine, Conjugated estrogens, Cyclobenzaprine, Dacarbazine, Dapagliflozin, Dasatinib, Deutetrabenazine, Dexfenfluramine, Diclofenac, Dihydralazine, Disopyramide, Domperidone, Doxepin, Doxofylline, Duloxetine, Efavirenz, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Etamiphylline, Ethanol, Ethinylestradiol, Etoposide, Etoricoxib, Fenethylline, Fenfluramine, Flecainide, Flunarizine, Fluorouracil, Fluoxetine, Flutamide, Fluvoxamine, Frovatriptan, Genistein, Grepafloxacin, GTS-21, Guanabenz, Haloperidol, Hesperetin, Hypoxanthine, Icotinib, Imatinib, Imipramine, Ixazomib, Leflunomide, Levobupivacaine, Lidocaine, Lisofylline, Lofexidine, Lomefloxacin, Lonafarnib, Lopinavir, Loratadine, Lorcaserin, Lumiracoxib, Malathion, Maprotiline, Melatonin, Mephenytoin, Methadone, Methoxyflurane, Metoclopramide, Mexiletine, Mianserin, Mirtazapine, Muraglitazar, Nabumetone, Naproxen, Nicotine, Nifedipine, Norethisterone, Nortriptyline, Olanzapine, Ondansetron, Oxtriphylline, Palonosetron, Paroxetine, Pazopanib, Pentifylline, Pentoxifylline, Perampanel, Perphenazine, Phenacetin, Pimobendan, Pimozide, Pirfenidone, Pomalidomide, Pralsetinib, Praziquantel, Primaquine, Promazine, Propacetamol, Propafenone, Propentofylline, Propranolol, Proxyphylline, Quinine, Ramelteon, Ramosetron, Ranitidine, Rasagiline, Resveratrol, Riluzole, Rofecoxib, Ropinirole, Ropivacaine, Rucaparib, Selegiline, Selumetinib, Sorafenib, Stiripentol, Tacrine, Tamoxifen, Tasimelteon, Tegafur, Temafloxacin, Terbinafine, Theobromine, Theophylline, Thiabendazole, Thiothixene, Tizanidine, Tocainide, Tolperisone, Triamterene, Triclabendazole, Trifluoperazine, Trimethoprim, Ulipristal, Umifenovir, Vadimezan, Verapamil, Voxilaprevir, Warfarin, Xanthine, Zileuton, Zolmitriptan, Zolpidem, Zotepine
2	Cytochrome P450 1A2 inhibitors	Abametapir, Abemaciclib, Abiraterone, Albinterferon Alfa-2B, Alosetron, Amiodarone, Anagrelide, Anastrozole, Atazanavir, Avasimibe, Besifloxacin, Black cohosh, Bortezomib, Caffeine, Cannabidiol, Capmatinib, Carbamazepine, Cepeginterferon alfa-2B, Cimetidine, Cinoxacin, Ciprofloxacin, Citalopram, Clascoterone, Clinafloxacin, Clozapine, Conjugated estrogens, Curcumin, Curcumin sulfate, Deferasirox, Dexmedetomidine, Diacerein, Difloxacin, Dihydralazine, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Enoxacin, Enrofloxacin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Famotidine, Flumequine, Fluoxetine, Fluvoxamine, Furafylline, Garenoxacin, Gatifloxacin, Gemfibrozil, Gemifloxacin, Genistein, Grepafloxacin, Imipramine, Interferon alfa, Interferon alfa-2a, Interferon alfa-2b, Interferon alfa-2c, Interferon alfa-n1, Interferon alfa-n3, Interferon alfacon-1, Interferon beta-1a, Interferon beta-1b, Interferon gamma-1b, Isoniazid, Ketoconazole, Lenvatinib, Levofloxacin, Lidocaine, Lobeglitazone, Lomefloxacin, Lopinavir, Medical Cannabis, Methimazole, Methoxsalen, Methylene blue, Mexiletine, Mibefradil, Midostaurin, Moxifloxacin, Nabiximols, Nalidixic acid, Nemonoxacin, Nevirapine, Niclosamide, Nifedipine, Nitric Oxide, Norfloxacin, Obeticholic acid, Ofloxacin, Ondansetron, Orbifloxacin, Orphenadrine, Osilodrostat, Oxolinic acid, Paroxetine, Pazufloxacin, Pefloxacin, Peginterferon alfa-2a, Peginterferon alfa-2b, Peginterferon beta-1a, Peppermint oil, Pipemidic acid, Promazine, Propafenone, Propofol, Prulifloxacin, Quinidine, Ranitidine, Remoxipride, Resveratrol, Rhein, Rifamycin, Rofecoxib, Ropeginterferon alfa-2b, Rosiglitazone, Rosoxacin, Rucaparib, Rufloxacin, Safinamide, Sarafloxacin, Selegiline, Simeprevir, Sitafloxacin, Sparfloxacin, Stiripentol, Sulconazole, Technetium Tc-99m ciprofloxacin, Tegaserod, Temafloxacin, Thiabendazole, Ticlopidine, Tirbanibulin, Tocainide, Tranylcypromine, Triclabendazole, Trovafloxacin, Valproic acid, Vemurafenib, Viloxazine, Zafirlukast, Zucapsaicin
3	Cytochrome P450 1A2 inducers	Albendazole, Armodafinil, Belinostat, beta-Naphthoflavone, Capsaicin, Carbamazepine, Dovitinib, Fosphenytoin, Griseofulvin, Insulin aspart, Insulin beef, Insulin degludec, Insulin detemir, Insulin glargine, Insulin glulisine, Insulin human, Insulin lispro, Insulin peglispro, Insulin pork, Insulin tregopil, Menadione, Meperidine, Methylene blue, Midostaurin, Modafinil, Nafcillin, Nicotine, NN344, Omeprazole, Osimertinib, Phenobarbital, Phenylephrine, Phenytoin, Pitolisant, Primaquine, Primidone, Rabeprazole, Rifampicin, Ritonavir, Rucaparib, Secobarbital, Somapacitan, Streptozocin, Teriflunomide

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 2B6 substrate
1	Cytochrome P450 2B6 substrates	Amitriptyline, Amlodipine, Antipyrine, Apomorphine, Artemether, Artemisinin, Asunaprevir, Banoxantrone, Benzphetamine, Brivaracetam, Bupropion, Carbamazepine, Cenobamate, Cinnarizine, Cisapride, Clobazam, Clomethiazole, Clopidogrel, Clotiazepam, Cyclophosphamide, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Domperidone, Efavirenz, Enasidenib, Epinastine, Esketamine, Estrone, Ethylmorphine, Fenfluramine, Flunitrazepam, Fluoxetine, Halothane, Hydrocodone, Ifosfamide, Imipramine, Irinotecan, Isoflurane, Ixazomib, Ketamine, Ketobemidone, Lidocaine, Loperamide, Loratadine, Lorcaserin, Malathion, Meperidine, Mephenytoin, Methadone, Methoxyflurane, Methylphenobarbital, Methyltestosterone, Mexiletine, Mianserin, Nevirapine, Nicotine, Norgestimate, Osilodrostat, Ospemifene, Perampanel, Perhexiline, Permethrin, Phenytoin, Prasugrel, Promethazine, Propofol, Romidepsin, Ropivacaine, Selegiline, Seratrodast, Sertraline, Sevoflurane, Tamoxifen, Temazepam, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tramadol, Tretinoin, Trifarotene, Valproic acid, Velpatasvir, Verapamil, Vortioxetine, Voxelotor
2	Cytochrome P450 2B6 inducers	Armodafinil, Artemether, Artemisinin, Atorvastatin, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cerivastatin, Clotrimazole, Cyclophosphamide, Dabrafenib, Dexamethasone, Dexamethasone acetate, Efavirenz, Enasidenib, Esketamine, Fluvastatin, Fosphenytoin, Hydrocortisone, Idelalisib, Isavuconazole, Isoflurane, Ivosidenib, Lemborexant, Letermovir, Lorlatinib, Lumacaftor, Metamizole, Methadone, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nicardipine, Nifedipine, Nilotinib, Olaparib, Perampanel, Permethrin, Pexidartinib, Phenobarbital, Phenytoin, Pitolisant, Prednisolone phosphate, Prednisone, Relugolix, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Simvastatin, Sulfinpyrazone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Troglitazone, Vemurafenib, Zanubrutinib
3	Cytochrome P450 2B6 inhibitors	Abametapir, Abemaciclib, Amlodipine, Amprenavir, Azelastine, Cenobamate, Cisplatin, Clascoterone, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Crizotinib, Curcumin, Curcumin sulfate, Desipramine, Doxorubicin, Elexacaftor, Enasidenib, Enzalutamide, Ethanol, Fluvoxamine, Isoflurane, Itraconazole, Ketoconazole, Lenvatinib, Lopinavir, Manidipine, Memantine, Methimazole, Methylene blue, Miconazole, Modafinil, Nelfinavir, Nitric Oxide, Orphenadrine, Paroxetine, Pexidartinib, Phencyclidine, Piperaquine, Quazepam, Quinidine, Raloxifene, Regorafenib, Rifamycin, Rilpivirine, Ritonavir, Roxithromycin, Safinamide, Selegiline, Sertraline, Simvastatin, Sorafenib, Sulfaphenazole, Tamoxifen, Thiotepa, Ticlopidine, Tirbanibulin, Triclabendazole, Voriconazole
4	Cytochrome P450 2B6 activators	Verapamil

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 2C8 substrate
1	Cytochrome P450 2C8 substrates	(R)-warfarin, (S)-Warfarin, Almotriptan, Aminophenazone, Amiodarone, Amitriptyline, Amodiaquine, Anastrozole, Antipyrine, Apalutamide, Apixaban, Apomorphine, Atorvastatin, Azelastine, Balaglitazone, Benzyl alcohol, Beraprost, Bioallethrin, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Capravirine, Carbamazepine, Celecoxib, Cerivastatin, Chloroquine, Ciglitazone, Cisapride, Clozapine, Cyclophosphamide, Dabrafenib, Dapsone, Dasabuvir, Dexibuprofen, Diazepam, Diclofenac, Diethylstilbestrol, Diltiazem, Domperidone, Elagolix, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Eszopiclone, Ethinylestradiol, Fluorouracil, Fluvastatin, Glasdegib, Halofantrine, Hydroxychloroquine, Ibuprofen, Ifosfamide, Imatinib, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Ketorolac, Lansoprazole, Lapatinib, Levomilnacipran, Licofelone, Lidocaine, Lobeglitazone, Lonafarnib, Loperamide, Loratadine, Lorlatinib, Lovastatin, Meloxicam, Mephenytoin, Mestranol, Methadone, Montelukast, Morphine, Muraglitazar, Mycophenolate mofetil, Naproxen, Netoglitazone, Nicardipine, Nicotine, Odanacatib, Olodaterol, Ombitasvir, Omeprazole, Ozanimod, Paclitaxel, Paramethadione, Pazopanib, Perospirone, Perphenazine, Phenprocoumon, Phenytoin, Pioglitazone, Piroxicam, Pitavastatin, Ponatinib, Propofol, Quinine, Relugolix, Remdesivir, Repaglinide, Riociguat, Rivoglitazone, Rosiglitazone, Selegiline, Selexipag, Selumetinib, Seratrodast, Simvastatin, Sitagliptin, Sorafenib, Sulfadiazine, Tazarotene, Tegafur, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tirbanibulin, Tolbutamide, Torasemide, Tretinoin, Trifarotene, Trimethadione, Trimethoprim, Troglitazone, Tucatinib, Velpatasvir, Verapamil, Vortioxetine, Voxilaprevir, Warfarin, Zopiclone
2	Cytochrome P450 2C8 inducers	Avatrombopag, Betamethasone, Budesonide, Carbamazepine, Cenobamate, Cyclophosphamide, Dexamethasone, Dexamethasone acetate, Hydrocortisone, Hydrocortisone aceponate, Hydrocortisone acetate, Hydrocortisone butyrate, Hydrocortisone cypionate, Hydrocortisone phosphate, Hydrocortisone probutate, Hydrocortisone succinate, Hydrocortisone valerate, Ifosfamide, Isavuconazole, Ivosidenib, Lumacaftor, Methylprednisolone, Midostaurin, Nilotinib, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Probenecid, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Rifaximin, Ritonavir, Secobarbital
3	Cytochrome P450 2C8 inhibitors	Abemaciclib, Abiraterone, Alpelisib, Amitriptyline, Amlodipine, Amoxicillin, Anastrozole, Atazanavir, Atorvastatin, Balaglitazone, Belinostat, Bexarotene, Bezafibrate, Bosutinib, Cabozantinib, Candesartan, Candesartan cilexetil, Cerivastatin, Cholecalciferol, Ciglitazone, Cimetidine, Clascoterone, Clofazimine, Clopidogrel, Clotrimazole, Colchicine, Crisaborole, Dabrafenib, Deferasirox, Diethylstilbestrol, Efavirenz, Elexacaftor, Eltrombopag, Enasidenib, Enzalutamide, Erlotinib, Ethinylestradiol, Ezetimibe, Favipiravir, Felodipine, Fenofibrate, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Gemfibrozil, Genistein, Idelalisib, Irbesartan, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lapatinib, Lenvatinib, Letermovir, Levothyroxine, Licofelone, Liotrix, Lobeglitazone, Lonafarnib, Loratadine, Losartan, Lumacaftor, Lumasiran, Medroxyprogesterone acetate, Mefenamic acid, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Mometasone, Mometasone furoate, Montelukast, Nabilone, Netoglitazone, Nicardipine, Nifedipine, Nilotinib, Nilvadipine, Opicapone, Oxybutynin, Pazopanib, Phenelzine, Pioglitazone, Ponatinib, Pralsetinib, Pyrimethamine, Quercetin, Quinidine, Quinine, Rabeprazole, Raloxifene, Regorafenib, Rifamycin, Ripretinib, Ritonavir, Rivoglitazone, Rofecoxib, Rosiglitazone, Rucaparib, Salmeterol, Saquinavir, Selpercatinib, Simvastatin, Sorafenib, Spironolactone, Sulfaphenazole, Sulfinpyrazone, Tamoxifen, Tegaserod, Terfenadine, Teriflunomide, Ticlopidine, Tirbanibulin, Tolbutamide, Topiroxostat, Trametinib, Triazolam, Triclabendazole, Trimethoprim, Troglitazone, Troleandomycin, Ubrogepant, Vemurafenib, Verapamil, Vismodegib, Warfarin, Zafirlukast

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 2C9 substrate
1	Cytochrome P450 2C9 inhibitors	Abemaciclib, Abiraterone, Acetyl sulfisoxazole, Agomelatine, Amiodarone, Amodiaquine, Anastrozole, Aprepitant, Armodafinil, Atazanavir, Atorvastatin, Atovaquone, Avasimibe, Azelastine, Belinostat, Benzbromarone, Bicalutamide, Black cohosh, Bortezomib, Candesartan, Capecitabine, Ceritinib, Cerivastatin, Cimetidine, Cisapride, Cisplatin, Clascoterone, Clevidipine, Clinafloxacin, Clopidogrel, Clotrimazole, Crisaborole, Curcumin, Curcumin sulfate, Cyclizine, Delavirdine, Dexloxiglumide, Diacerein, Diethylstilbestrol, Doconexent, Dosulepin, Efavirenz, Elexacaftor, Enasidenib, Epinephrine, Estrone sulfate, Ethanol, Etoricoxib, Etravirine, Felbamate, Felodipine, Fenofibrate, Flecainide, Floxuridine, Fluconazole, Fluorouracil, Fluoxetine, Fluvastatin, Fluvoxamine, Gefitinib, Gemfibrozil, Genistein, Ginkgo biloba, Glyburide, Imatinib, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Ketoprofen, Lansoprazole, Leflunomide, Lenvatinib, Levofloxacin, Lifitegrast, Lobeglitazone, Lopinavir, Lumacaftor, Manidipine, Medical Cannabis, Medroxyprogesterone acetate, Methimazole, Methylene blue, Metronidazole, Miconazole, Midostaurin, Mifepristone, Modafinil, Nabilone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Noscapine, Olanzapine, Oritavancin, Oxandrolone, Paroxetine, Pexidartinib, Phenylbutazone, Phenytoin, Pralsetinib, Pranlukast, Probenecid, Progesterone, Promethazine, Quinidine, Rabeprazole, Regorafenib, Rhein, Rifamycin, Rucaparib, Safinamide, Seproxetine, Sertraline, Sildenafil, Simvastatin, Sitaxentan, Sorafenib, Stiripentol, Sulconazole, Sulfadiazine, Sulfadimethoxine, Sulfamethizole, Sulfamethoxazole, Sulfamoxole, Sulfaphenazole, Sulfapyridine, Sulfinpyrazone, Sulfisoxazole, Suprofen, Tamoxifen, Teniposide, Ticagrelor, Ticlopidine, Tienilic acid, Tirbanibulin, Tolcapone, Topiroxostat, Torasemide, Tranylcypromine, Troglitazone, Ubrogepant, Valdecoxib, Valproic acid, Vemurafenib, Verapamil, Vismodegib, Voriconazole, Zafirlukast, Zucapsaicin
2	Cytochrome P450 2C9 substrates	(R)-warfarin, (S)-Warfarin, Aceclofenac, Acenocoumarol, Acetohexamide, Acetylsalicylic acid, Alosetron, Alprazolam, Aminophenazone, Amitriptyline, Amprenavir, Antipyrine, Apixaban, Arachidonic Acid, Arformoterol, Artemether, Asunaprevir, Atazanavir, Avapritinib, Azelastine, Bioallethrin, Bortezomib, Bosentan, Brivaracetam, Buprenorphine, Bupropion, Cabozantinib, Caffeine, Candesartan, Candesartan cilexetil, Cannabidiol, Capecitabine, Capravirine, Carbutamide, Carvedilol, Celecoxib, Chlorpropamide, Cinnarizine, Clopidogrel, Clozapine, Coumarin, Cyclophosphamide, Dacomitinib, Dapagliflozin, Dapsone, Desogestrel, Dexibuprofen, Dexloxiglumide, Dextromethorphan, Diazepam, Diclofenac, Dicoumarol, Diphenhydramine, Doconexent, Dolasetron, Donepezil, Dorzolamide, Doxazosin, Doxepin, Dronabinol, Duloxetine, Eletriptan, Enasidenib, Enzalutamide, Erdafitinib, Esketamine, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Estrone sulfate, Ethinylestradiol, Etodolac, Etoricoxib, Etravirine, Fenfluramine, Fluindione, Flunarizine, Flunitrazepam, Fluoxetine, Flurbiprofen, Fluvastatin, Formoterol, Fosphenytoin, Glibornuride, Gliclazide, Glimepiride, Glipizide, Gliquidone, Glisoxepide, Glyburide, Haloperidol, Halothane, Hexobarbital, Hydromorphone, Ibuprofen, Idarubicin, Ifosfamide, Imatinib, Indisulam, Indomethacin, Irbesartan, Ixazomib, Ketamine, Ketobemidone, Ketoprofen, Ketorolac, Lacosamide, Leflunomide, Lesinurad, Licofelone, Lidocaine, Lonafarnib, Loratadine, Lornoxicam, Losartan, Lumiracoxib, Lynestrenol, Medical Cannabis, Mefenamic acid, Melatonin, Meloxicam, Mephenytoin, Mestranol, Metahexamide, Methadone, Methoxyflurane, Moclobemide, Montelukast, Nabiximols, Nabumetone, Naproxen, Nateglinide, Netupitant, Niclosamide, Nicotine, Norgestimate, Oliceridine, Olodaterol, Omeprazole, Ondansetron, Ospemifene, Paramethadione, Parecoxib, Perphenazine, Phenacetin, Phenobarbital, Phenprocoumon, Phenylbutazone, Phenytoin, Piperaquine, Pirfenidone, Piroxicam, Pitavastatin, Prasugrel, Primidone, Progesterone, Proguanil, Promazine, Propacetamol, Propofol, Quazepam, Quinidine, Quinine, Ramelteon, Rimegepant, Rofecoxib, Rosiglitazone, Rosuvastatin, Rupatadine, Salicylic acid, Selegiline, Selumetinib, Seratrodast, Sertraline, Sildenafil, Siponimod, Sitaxentan, Sulfamethoxazole, Suprofen, Tamoxifen, Tapentadol, Temazepam, Tenoxicam, Terbinafine, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Thalidomide, Thiamylal, Tolazamide, Tolbutamide, Tolterodine, Torasemide, Trabectedin, Tranilast, Treprostinil, Tretinoin, Triclabendazole, Trifarotene, Trimethadione, Trimethoprim, Trimipramine, Troglitazone, Umifenovir, Valdecoxib, Valproic acid, Valsartan, Verapamil, Vicriviroc, Vismodegib, Voriconazole, Vortioxetine, Voxelotor, Warfarin, Ximelagatran, Zafirlukast, Zaltoprofen, Zidovudine, Zileuton, Zolpidem, Zopiclone
3	Cytochrome P450 2C9 inducers	Alpelisib, Apalutamide, Aprepitant, Avatrombopag, Betamethasone, Bosentan, Budesonide, Carbamazepine, Dabrafenib, Dapsone, Delafloxacin, Enzalutamide, Etravirine, Fosaprepitant, Fosphenytoin, Hydrocortisone, Isavuconazole, Ivosidenib, Lansoprazole, Letermovir, Lopinavir, Lumacaftor, Methylprednisolone, Midostaurin, Modafinil, Nevirapine, Nifedipine, Peginterferon alfa-2b, Phenobarbital, Phenytoin, Pralsetinib, Prednisolone phosphate, Prednisone, Primidone, Rifabutin, Rifampicin, Rifamycin, Rifapentine, Ritonavir, Secobarbital, Vigabatrin, Warfarin
4	Cytochrome P450 2C9 inactivators	Suprofen

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 2C18 substrate
1	Cytochrome P450 2C18 substrates	(R)-warfarin, (S)-Warfarin, Aminophenazone, Antipyrine, Buprenorphine, Clobazam, Clotiazepam, Cyclophosphamide, Dapsone, Diazepam, Diclofenac, Etizolam, Ifosfamide, Imipramine, Lansoprazole, Methadone, Omeprazole, Perphenazine, Phenobarbital, Phenytoin, Propofol, Tolbutamide, Tretinoin, Verapamil, Warfarin
2	Cytochrome P450 2C18 inhibitors	Pegvisomant

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 2D6 substrate
1	Cytochrome P450 2D6 substrates	4-Methoxyamphetamine, 5-methoxy-N,N-dimethyltryptamine, Acebutolol, Acetaminophen, Almotriptan, Alogliptin, Alprenolol, Aminophenazone, Amitriptyline, Amoxapine, Amphetamine, Amprenavir, Anisodamine, Antipyrine, Aprindine, Arformoterol, Aripiprazole, Aripiprazole lauroxil, Arotinolol, Asenapine, Astemizole, Asunaprevir, Atenolol, Atomoxetine, Azelastine, Azimilide, Befunolol, Benzyl alcohol, Bepridil, Betaxolol, Bevantolol, Bicifadine, Bopindolol, Bortezomib, Brexpiprazole, Bucindolol, Bufuralol, Bupivacaine, Bupranolol, Buprenorphine, Buspirone, Butyrfentanyl, Caffeine, Cannabidiol, Cariprazine, Carteolol, Carvedilol, Celecoxib, Celiprolol, Cevimeline, Chloroquine, Chlorpheniramine, Chlorpromazine, Chlorzoxazone, Ciclesonide, Cilostazol, Cinnarizine, Citalopram, Clevidipine, Clomipramine, Clonidine, Cloranolol, Clozapine, Codeine, Cyclobenzaprine, Dacomitinib, Dapagliflozin, Dapoxetine, Darifenacin, Dasabuvir, Debrisoquine, Delavirdine, Desipramine, Deutetrabenazine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dextroamphetamine, Dextromethorphan, Dextropropoxyphene, Dihydrocodeine, Diltiazem, Diphenhydramine, Dolasetron, Domperidone, Donepezil, Dosulepin, Doxazosin, Doxepin, Dronedarone, Duloxetine, Elagolix, Eletriptan, Eliglustat, Enasidenib, Encainide, Enclomiphene, Encorafenib, Epanolol, Epinastine, Erlotinib, Esatenolol, Escitalopram, Esmirtazapine, Esmolol, Ethylmorphine, Fenfluramine, Fesoterodine, Flecainide, Flunarizine, Fluoxetine, Fluvastatin, Fluvoxamine, Formoterol, Fusidic acid, Galantamine, Gefitinib, Haloperidol, Hydrocodone, Hydroxychloroquine, Ibrutinib, Idarubicin, Iloperidone, Imatinib, Imipramine, Indenolol, Ipecac, Ixazomib, Labetalol, Landiolol, Letermovir, Levobetaxolol, Levobunolol, Levomilnacipran, Lidocaine, Lisdexamfetamine, Lofexidine, Loperamide, Lopinavir, Loratadine, Lorcaserin, Lorpiprazole, Lysergic acid diethylamide, Maprotiline, Meclizine, Meperidine, Mephenytoin, Mepindolol, Mequitazine, Mesoridazine, Metamfetamine, Methadone, Methotrimeprazine, Methoxyflurane, Metipranolol, Metoclopramide, Metoprolol, Mexiletine, Mianserin, Midodrine, Midomafetamine, Minaprine, Mirabegron, Mirtazapine, Moclobemide, Nabiximols, Nateglinide, Nebivolol, Nefazodone, Netupitant, Nevirapine, Nicergoline, Nicotine, Nortriptyline, Olanzapine, Oliceridine, Ondansetron, Opium, Osilodrostat, Oxamniquine, Oxprenolol, Oxycodone, Oxymorphone, Paliperidone, Palonosetron, Paroxetine, Penbutolol, Pentamidine, Perhexiline, Perospirone, Perphenazine, Phenacetin, Phenformin, Phenytoin, Pindolol, Piperazine, Pipotiazine, Pirfenidone, Pitolisant, Ponatinib, Practolol, Pralsetinib, Procainamide, Prochlorperazine, Progesterone, Promazine, Promethazine, Propacetamol, Propafenone, Propranolol, Quetiapine, Quinine, Ranolazine, Remdesivir, Remoxipride, Repinotan, Revefenacin, Ripretinib, Risperidone, Ritonavir, Rotigotine, Rucaparib, Rupatadine, Selegiline, Sertindole, Sertraline, Sildenafil, Simvastatin, Solifenacin, Sotalol, Sparteine, Tafenoquine, Talinolol, Tamoxifen, Tamsulosin, Tapentadol, Tegaserod, Terfenadine, Tertatolol, Tesmilifene, Tetrabenazine, Theophylline, Thioridazine, Ticlopidine, Timolol, Tiotropium, Tipranavir, Tolterodine, Trabectedin, Tramadol, Trazodone, Triclabendazole, Trimipramine, Umeclidinium, Umifenovir, Upadacitinib, Valbenazine, Venlafaxine, Vernakalant, Vilazodone, Vortioxetine, Yohimbine, Zolpidem, Zuclopenthixol
2	Cytochrome P450 2D6 inhibitors	1-(2-Phenylethyl)-4-phenyl-4-acetoxypiperidine, Abemaciclib, Abiraterone, Acebutolol, Amiodarone, Amlodipine, Amodiaquine, Amoxapine, Artenimol, Asenapine, Asunaprevir, Atorvastatin, Azelastine, Bepridil, Berotralstat, Bicalutamide, Biperiden, Black cohosh, Buprenorphine, Bupropion, Cannabidiol, Celecoxib, Cerivastatin, Chloroquine, Chlorpheniramine, Chlorpromazine, Cimetidine, Cinacalcet, Cisapride, Citalopram, Clascoterone, Clemastine, Clinafloxacin, Clobazam, Clofazimine, Clomipramine, Clotrimazole, Clozapine, Cobicistat, Cocaine, Curcumin, Curcumin sulfate, Cyclosporine, Dacomitinib, Dapoxetine, Darifenacin, Darunavir, Delavirdine, Deramciclane, Desipramine, Desvenlafaxine, Dexchlorpheniramine, Dexchlorpheniramine maleate, Dexfenfluramine, Dexmedetomidine, Dextropropoxyphene, Diacerein, Dimethyl sulfoxide, Diphenhydramine, Dosulepin, Doxepin, Doxorubicin, Dronedarone, Duloxetine, Efavirenz, Elexacaftor, Eliglustat, Enasidenib, Entacapone, Epinastine, Escitalopram, Etoricoxib, Everolimus, Fedratinib, Felodipine, Fenfluramine, Flecainide, Fluoxetine, Fluphenazine, Fluvoxamine, Fusidic acid, Gefitinib, Glycerol phenylbutyrate, Halofantrine, Haloperidol, Hydroxychloroquine, Hydroxyurea, Hydroxyzine, Imatinib, Imipramine, Indinavir, Indisulam, Iproniazid, Isavuconazole, Isoniazid, Ketoconazole, Labetalol, Lansoprazole, Lasmiditan, Lenvatinib, Lercanidipine, Levosalbutamol, Lidocaine, Lisdexamfetamine, Lomustine, Loratadine, Lorcaserin, Lumefantrine, Manidipine, Medical Cannabis, Melperone, Mepyramine, Methadone, Methimazole, Methotrimeprazine, Methylene blue, Metoclopramide, Metoprolol, Mibefradil, Miconazole, Midostaurin, Mifepristone, Mirabegron, Mizolastine, Moclobemide, Nabiximols, Naloxegol, Nefazodone, Nelfinavir, Nevirapine, Niacin, Nicardipine, Nicotinamide, Nifedipine, Nilotinib, Nortriptyline, Olanzapine, Omeprazole, Oritavancin, Orphenadrine, Osilodrostat, Ospemifene, Oxamniquine, Oxprenolol, Oxybutynin, Oxymetholone, Panobinostat, Paroxetine, Pazopanib, Peginterferon alfa-2b, Perhexiline, Perphenazine, Phenelzine, Phenylbutyric acid, Pimozide, Pindolol, Pipotiazine, Pitolisant, Primaquine, Proguanil, Promethazine, Propafenone, Propranolol, Quinidine, Quinine, Rabeprazole, Ranitidine, Ranolazine, Reboxetine, Rhein, Rilpivirine, Risperidone, Ritanserin, Ritonavir, Rolapitant, Rosiglitazone, Rotigotine, Rucaparib, Safinamide, Saquinavir, Selegiline, Sertraline, Sorafenib, Sparteine, St. John's Wort, Stiripentol, Sulconazole, Sulfanilamide, Sulfaphenazole, Tamoxifen, Tapentadol, Tegaserod, Temsirolimus, Terbinafine, Terfenadine, Thioridazine, Thiothixene, Ticlopidine, Tipranavir, Tirbanibulin, Tranylcypromine, Trazodone, Triclabendazole, Tripelennamine, Trospium, Ubrogepant, Vemurafenib, Venlafaxine, Verapamil, Vernakalant, Vinblastine, Vinorelbine
3	Cytochrome P450 2D6 inducers	Oritavancin

	Interacting Group	Interacting Drugs
	Istradefylline is a Cytochrome P450 3A Subfamily inhibitor
1	Cytochrome P450 3A Subfamily inhibitors	Crizotinib, Diacerein, Fluvoxamine, Glecaprevir, Lemborexant, Lonafarnib, Lopinavir, Lorlatinib, Midostaurin, Nefazodone, Olanzapine, Phenelzine, Pibrentasvir, Remoxipride, Rhein, Risdiplam, Selpercatinib
2	Cytochrome P450 3A Subfamily substrates	Acalabrutinib, Ambroxol acefyllinate, Budesonide, Dolutegravir, Elagolix, Ethosuximide, Foretinib, Glecaprevir, Lonafarnib, Lorlatinib, Loxoprofen, Mebendazole, Methylprednisolone, Midostaurin, Mirodenafil, Moxisylyte, Naldemedine, Omega-3-carboxylic acids, Relugolix, Tazemetostat, Thiopental, Tucatinib, Zanubrutinib
3	Cytochrome P450 3A Subfamily inducers	Brigatinib, Budesonide, Lemborexant, Methylprednisolone, Midostaurin, Myrrh, Prednisolone phosphate, Prednisone, Relugolix, Rifapentine

	Interacting Group	Interacting Drugs
	Istradefylline is a P-glycoprotein 1 inhibitor
1	P-glycoprotein 1 inducers	Acetylsalicylic acid, Aldosterone, Amiodarone, Amprenavir, Apalutamide, Atazanavir, Beclomethasone dipropionate, Betamethasone phosphate, Carbamazepine, Cholic Acid, Cimetidine, Clotrimazole, Colchicine, Darunavir, Daunorubicin, Dexamethasone, Dexamethasone acetate, Diclofenac, Digoxin, Doxorubicin, Estriol, Estrone, Etravirine, Hydrocortisone, Indinavir, Ivermectin, Levothyroxine, Liothyronine, Liotrix, Lopinavir, Lumacaftor, Methylprednisolone, Mifepristone, Mitoxantrone, Nefazodone, Nelfinavir, Nifedipine, Phenobarbital, Platelet Activating Factor, Prednisolone phosphate, Prednisone, Progesterone, Propofol, Reserpine, Rifabutin, Rifampicin, Ritonavir, Saquinavir, Sirolimus, Spironolactone, St. John's Wort, Streptozocin, Tacrolimus, Tamoxifen, Tesmilifene, Tipranavir, Trazodone, Vinblastine, Vincristine
2	P-glycoprotein 1 inhibitors	Abemaciclib, Acetaminophen, Afatinib, Alectinib, Alfentanil, Alpelisib, Amiodarone, Amlodipine, Amodiaquine, Amsacrine, Arsenic trioxide, Astemizole, Asunaprevir, Atazanavir, Atorvastatin, Atovaquone, Axitinib, Azelastine, Azithromycin, Benzocaine, Bepridil, Berotralstat, Bicalutamide, Biricodar, Bisoprolol, Boceprevir, Bromocriptine, Buprenorphine, Buspirone, Cabazitaxel, Canagliflozin, Candesartan, Candesartan cilexetil, Captopril, Carfilzomib, Carvedilol, Caspofungin, Ceftriaxone, Cethromycin, Cetirizine, Chloroquine, Chlorpromazine, Chlorprothixene, Cholesterol, Cilazapril, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clotrimazole, Cobicistat, Colforsin, Concanamycin A, Conivaptan, Crizotinib, Curcumin, Cyclosporine, Daclatasvir, Dacomitinib, Dactinomycin, Darunavir, Dasatinib, Daunorubicin, Desipramine, Desloratadine, Desmethylsertraline, Dexamethasone, Dexamethasone acetate, Dexniguldipine, Dexverapamil, Digoxin, Dihydroergotamine, Diltiazem, Dipyridamole, Dofequidar, Dovitinib, Doxazosin, Doxorubicin, Dronabinol, Dronedarone, Duloxetine, Elacridar, Elagolix, Elbasvir, Elexacaftor, Emopamil, Enalapril, Enasidenib, Entrectinib, Enzalutamide, Erdafitinib, Ergometrine, Ergotamine, Erlotinib, Erythromycin, Esomeprazole, Estramustine, Etoposide, Favipiravir, Fedratinib, Felodipine, Fentanyl, Fingolimod, Flibanserin, Fluconazole, Fluoxetine, Flupentixol, Fluphenazine, Flurazepam, Fluvoxamine, Galantamine, Gallopamil, Gefitinib, Genistein, Glasdegib, Glecaprevir, Glyburide, Gramicidin D, Grepafloxacin, Haloperidol, HM-30181, Hycanthone, Hydroxychloroquine, Idelalisib, Imatinib, Indinavir, Indomethacin, Isavuconazole, Isavuconazonium, Itraconazole, Ivacaftor, Ivermectin, Ivosidenib, Ixabepilone, Ketoconazole, Lamotrigine, Laniquidar, Lansoprazole, Lapatinib, Lasmiditan, Letermovir, Levofloxacin, Lidocaine, Lomerizine, Lomitapide, Lonafarnib, Lopinavir, Loratadine, Losartan, Lovastatin, Lumacaftor, Lurbinectedin, Medroxyprogesterone acetate, Mefloquine, Megestrol acetate, Methadone, Methylene blue, Metronidazole, Mibefradil, Miconazole, Mifepristone, Mirabegron, Mitotane, Mitoxantrone, Naproxen, Nefazodone, Nelfinavir, Neratinib, Netupitant, Nicardipine, Niguldipine, Nilotinib, Nintedanib, Nisoldipine, Nitrendipine, Norethisterone, Norgestimate, Olaparib, Omeprazole, ONT-093, Paclitaxel, Palbociclib, Paliperidone, Pantoprazole, Paroxetine, Pemigatinib, Pibrentasvir, Pimozide, Piperine, Polyethylene glycol, Polyethylene glycol 400, Ponatinib, Posaconazole, Pralsetinib, Prazosin, Primaquine, Progesterone, Promethazine, Propafenone, Protriptyline, Quercetin, Quinacrine, Quinidine, Quinine, Ranitidine, Ranolazine, Reboxetine, Regorafenib, Relugolix, Reserpine, Reversin 121, Rifamycin, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Salinomycin, Saquinavir, Sarecycline, Scopolamine, Selegiline, Selpercatinib, Sertraline, Sildenafil, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Staurosporine, Sunitinib, Tacrolimus, Tamoxifen, Tariquidar, Taurocholic acid, Telaprevir, Telmisartan, Temsirolimus, Tenofovir disoproxil, Terazosin, Terfenadine, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tetrandrine, Tezacaftor, Ticagrelor, Tipifarnib, Tipranavir, Tolvaptan, Trifluoperazine, Triflupromazine, Troleandomycin, Upadacitinib, Valinomycin, Valspodar, Vandetanib, Vardenafil, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vinblastine, Vincristine, Voacamine, Voxilaprevir, Zimelidine, Zonisamide, Zosuquidar
3	P-glycoprotein 1 substrates	Abemaciclib, Acebutolol, Acenocoumarol, Acetaminophen, Acetylsalicylic acid, Afatinib, Albendazole, Aldosterone, Aliskiren, Alitretinoin, alpha-Tocopherol acetate, Ambrisentan, Amitriptyline, Amlodipine, Amprenavir, Anastrozole, Apixaban, Apremilast, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Avatrombopag, Axitinib, Azathioprine, Azithromycin, Baricitinib, Beclomethasone dipropionate, Belantamab mafodotin, Belinostat, Berotralstat, Betamethasone, Betamethasone phosphate, Betrixaban, Bisoprolol, Bortezomib, Bosutinib, Bromocriptine, Budesonide, Cabazitaxel, Cabergoline, Camptothecin, Canagliflozin, Capmatinib, Carfilzomib, Celecoxib, Ceritinib, Cerivastatin, Cethromycin, Cetirizine, Chloramphenicol succinate, Chloroquine, Chlorpromazine, Cimetidine, Ciprofloxacin, Citalopram, Clarithromycin, Clindamycin, Clobazam, Clofazimine, Clomifene, Clopidogrel, Clozapine, Cobimetinib, Colchicine, Conjugated estrogens, Copanlisib, Crizotinib, Cyclosporine, Dabigatran etexilate, Dabrafenib, Daclatasvir, Dacomitinib, Dactinomycin, Dapagliflozin, Darolutamide, Dasabuvir, Dasatinib, Daunorubicin, Debrisoquine, Dexamethasone, Dexamethasone acetate, Diazepam, Diethylstilbestrol, Digitoxin, Digoxin, Diltiazem, Dipyridamole, Docetaxel, Dolutegravir, Domperidone, Doxepin, Doxorubicin, Duvelisib, Edoxaban, Elagolix, Elbasvir, Eletriptan, Elexacaftor, Eliglustat, Empagliflozin, Enasidenib, Enfortumab vedotin, Entrectinib, Epinastine, Erdafitinib, Erlotinib, Ertugliflozin, Erythromycin, Escitalopram, Esomeprazole, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estriol, Estrone, Ethinylestradiol, Etoposide, Everolimus, Ezetimibe, Fedratinib, Fesoterodine, Fexofenadine, Fidaxomicin, Filgotinib, Flecainide, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fostemsavir, Gefitinib, Gemcitabine, Gilteritinib, Glasdegib, Glecaprevir, Gramicidin D, Grapiprant, Grazoprevir, Grepafloxacin, Haloperidol, Hydrocortisone, Hydroxyzine, Ibuprofen, Idelalisib, Imatinib, Imipramine, Indacaterol, Indinavir, Indomethacin, Inotuzumab ozogamicin, Irinotecan, Ivermectin, Ivosidenib, Ixabepilone, Ketazolam, Lamivudine, Lamotrigine, Lansoprazole, Larotrectinib, Lasmiditan, Ledipasvir, Lefamulin, Lemborexant, Lenalidomide, Lenvatinib, Letermovir, Letrozole, Levamlodipine, Levetiracetam, Levofloxacin, Levomilnacipran, Linagliptin, Lonafarnib, Loperamide, Loratadine, Losartan, Lurbinectedin, Lusutrombopag, Medrysone, Mefloquine, Meperidine, Methotrexate, Methylene blue, Methylprednisolone, Metoclopramide, Mibefradil, Mirabegron, Mitoxantrone, Monensin, Morphine, Mycophenolate mofetil, Nadolol, Naloxone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Nintedanib, Nitrofurantoin, Nizatidine, Nortriptyline, Octreotide, Odanacatib, Olanzapine, Olaparib, Olopatadine, Omadacycline, Ombitasvir, Omeprazole, Osimertinib, Oxcarbazepine, Ozanimod, Paclitaxel, Palbociclib, Paliperidone, Panobinostat, Pantoprazole, Paritaprevir, Pazopanib, Pemigatinib, Pentazocine, Phenobarbital, Phenytoin, Pibrentasvir, Pitavastatin, Platelet Activating Factor, Pomalidomide, Ponatinib, Posaconazole, Pralsetinib, Pravastatin, Prazosin, Prednisolone, Prednisolone acetate, Prednisolone phosphate, Prednisone, Progesterone, Propranolol, Prucalopride, Quetiapine, Quinidine, Quinine, Raloxifene, Ranitidine, Ranolazine, Regorafenib, Relugolix, Remdesivir, Reserpine, Revefenacin, Rhodamine 6G, Rifamycin, Rimegepant, Ripretinib, Risdiplam, Risperidone, Ritonavir, Rivaroxaban, Romidepsin, Rucaparib, Saquinavir, Selexipag, Selpercatinib, Selumetinib, Sildenafil, Silodosin, Simeprevir, Sitagliptin, Sofosbuvir, Somatostatin, Sorafenib, Sparfloxacin, Sphingosine, Stanolone, Stanolone acetate, Sumatriptan, Tacrine, Tacrolimus, Talazoparib, Talinolol, Tamoxifen, Taurocholic acid, Tazemetostat, Technetium Tc-99m sestamibi, Tegaserod, Telaprevir, Temsirolimus, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Testosterone propionate, Tezacaftor, Ticagrelor, Timolol, Tipranavir, Tolvaptan, Topiramate, Topotecan, Toremifene, Trastuzumab deruxtecan, Trastuzumab emtansine, Trimethoprim, Trimipramine, Tucatinib, Ubidecarenone, Ubrogepant, Umeclidinium, Upadacitinib, Valinomycin, Vardenafil, Vecuronium, Velpatasvir, Vemurafenib, Venetoclax, Venlafaxine, Verapamil, Vibegron, Vinblastine, Vincristine, Vinflunine, Vismodegib, Voxilaprevir, Zanubrutinib, Zidovudine
4	P-glycoprotein 1 modulators	Acetylsalicylic acid, Avapritinib, Prazosin
5	P-glycoprotein 1 transporters	Ledipasvir, Tocopherol
6	P-glycoprotein 1 binders	Technetium Tc-99m tetrofosmin
7	P-glycoprotein 1 antagonists	Tocofersolan

	Interacting Group	Interacting Drugs
	Istradefylline is a ATP-binding cassette sub-family G member 2 inhibitor
1	ATP-binding cassette sub-family G member 2 substrates	Abemaciclib, Afatinib, Allopurinol, Alpelisib, Alvocidib, Apixaban, Artesunate, Baricitinib, Berotralstat, Brigatinib, Camptothecin, Carboplatin, Celecoxib, Cerivastatin, Cisplatin, Cladribine, Clofarabine, Conjugated estrogens, Copanlisib, Dabrafenib, Dacomitinib, Dactinomycin, Darolutamide, Dasatinib, Daunorubicin, Delafloxacin, Docetaxel, Dolutegravir, Donepezil, Doxorubicin, Duvelisib, Empagliflozin, Enasidenib, Ertugliflozin, Etoposide, Ezetimibe, Fimasartan, Fluorouracil, Folic acid, Fostemsavir, Gefitinib, Glasdegib, Glecaprevir, Glyburide, Idelalisib, Imatinib, Irinotecan, Ivermectin, Lamivudine, Larotrectinib, Leflunomide, Lenvatinib, Lusutrombopag, Methotrexate, Mitoxantrone, Mycophenolate mofetil, Nifurtimox, Nilotinib, Nitrofurantoin, Ombitasvir, Osimertinib, Oxaliplatin, Ozanimod, Palbociclib, Pantoprazole, Pazopanib, Pemigatinib, Pibrentasvir, Pitavastatin, Ponatinib, Pralatrexate, Pralsetinib, Prasterone, Pravastatin, Prazosin, Raloxifene, Revefenacin, Riluzole, Rimegepant, Riociguat, Ripretinib, Risdiplam, Rivaroxaban, Rosuvastatin, Rucaparib, Selpercatinib, Selumetinib, Simeprevir, Sofosbuvir, Sorafenib, Sulfasalazine, Sumatriptan, Talazoparib, Tamoxifen, Tazemetostat, Tegaserod, Teniposide, Tenofovir alafenamide, Teriflunomide, Testosterone, Testosterone cypionate, Testosterone enanthate, Testosterone undecanoate, Tezacaftor, Topotecan, Trastuzumab deruxtecan, Tucatinib, Ubrogepant, Upadacitinib, Velpatasvir, Vemurafenib, Vincristine, Voxilaprevir, Zidovudine
2	ATP-binding cassette sub-family G member 2 inhibitors	Abemaciclib, Afatinib, Alectinib, Avatrombopag, Baricitinib, Beclomethasone dipropionate, Brigatinib, Buprenorphine, Cabazitaxel, Caffeine, Cannabidiol, Capmatinib, Clofazimine, Cobicistat, Cyclosporine, Dabrafenib, Daclatasvir, Dacomitinib, Daidzin, Darolutamide, Dasabuvir, Dasatinib, Dexamethasone, Dexamethasone acetate, Diethylstilbestrol, Dovitinib, Dronabinol, Elacridar, Eltrombopag, Enasidenib, Erlotinib, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Fedratinib, Fostamatinib, Fostemsavir, Fusidic acid, Gefitinib, Genistein, Gilteritinib, Glasdegib, Glecaprevir, Hesperetin, Imatinib, Isavuconazole, Lansoprazole, Lasmiditan, Letermovir, Lonafarnib, Medical Cannabis, Nabiximols, Naringenin, Nelfinavir, Nilotinib, Novobiocin, Olaparib, Omeprazole, Palbociclib, Pantoprazole, Paritaprevir, Pibrentasvir, Ponatinib, Pralsetinib, Progesterone, Quercetin, Rabeprazole, Regorafenib, Relugolix, Rilpivirine, Ripretinib, Ritonavir, Rolapitant, Rucaparib, Safinamide, Saquinavir, Selpercatinib, Simeprevir, Sorafenib, Sulfasalazine, Sunitinib, Tafamidis, Taurocholic acid, Telmisartan, Teriflunomide, Topiroxostat, Upadacitinib, Vandetanib, Velpatasvir, Vemurafenib, Venetoclax, Vismodegib, Voxilaprevir
3	ATP-binding cassette sub-family G member 2 inducers	Apalutamide, Cholesterol, Dovitinib, Progesterone, Venlafaxine
4	ATP-binding cassette sub-family G member 2 antagonists	Zafirlukast
5	ATP-binding cassette sub-family G member 2 weak inhibitors	Cobimetinib
6	ATP-binding cassette sub-family G member 2 transporters	Ledipasvir
7	ATP-binding cassette sub-family G member 2 modulators	Avapritinib

	Interacting Group	Interacting Drugs
	Istradefylline is a Solute carrier organic anion transporter family member 1B1 inhibitor
1	Solute carrier organic anion transporter family member 1B1 substrates	Ambrisentan, Asunaprevir, Atorvastatin, Axitinib, Belantamab mafodotin, Benzylpenicillin, Cerivastatin, Cholecystokinin, Cholic Acid, Clotrimazole, Cobimetinib, Conjugated estrogens, Cyclosporine, Digoxin, Dinoprostone, Elagolix, Eluxadoline, Empagliflozin, Erythromycin, Ezetimibe, Fexofenadine, Fimasartan, Fluvastatin, Gadoxetic acid, Gimatecan, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Lovastatin, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paritaprevir, Penicillamine, Pitavastatin, Prasterone, Pravastatin, Raloxifene, Remdesivir, Repaglinide, Revefenacin, Rosuvastatin, Selexipag, Simeprevir, Simvastatin, Sumatriptan, Taurocholic acid, Technetium Tc-99m mebrofenin, Tenofovir alafenamide, Torasemide, Ubrogepant, Valsartan, Voxilaprevir
2	Solute carrier organic anion transporter family member 1B1 inhibitors	Acetylcysteine, Aminohippuric acid, Amprenavir, Artesunate, Asunaprevir, Atazanavir, Atorvastatin, Axitinib, Beclomethasone dipropionate, Bempedoic acid, Benzbromarone, Bezafibrate, Cabazitaxel, Candesartan, Caspofungin, Cerivastatin, Cholecystokinin, Cholic Acid, Clarithromycin, Clotrimazole, Cobicistat, Conjugated estrogens, Cyclosporine, Dabrafenib, Daclatasvir, Darolutamide, Darunavir, Diclofenac, Diethylstilbestrol, Digoxin, Dipyridamole, Dovitinib, Dronedarone, Elexacaftor, Eltrombopag, Eluxadoline, Enasidenib, Erythromycin, Estradiol, Estradiol acetate, Estradiol benzoate, Estradiol cypionate, Estradiol dienanthate, Estradiol valerate, Estrone, Everolimus, Fedratinib, Fluticasone, Fluticasone furoate, Fluticasone propionate, Fluvastatin, Fostemsavir, Gemfibrozil, Genistein, Glecaprevir, Hyperforin, Idelalisib, Indinavir, Indomethacin, Irinotecan, Ivermectin, Ketoconazole, Lenvatinib, Levocarnitine, Levothyroxine, Lobeglitazone, Lonafarnib, Lopinavir, Lovastatin, Lurbinectedin, Mifepristone, Nelfinavir, Nicardipine, Nifedipine, Nilotinib, Novobiocin, Nystatin, Osilodrostat, Ouabain, Paritaprevir, Pazopanib, Pexidartinib, Pibrentasvir, Pioglitazone, Pitavastatin, Posizolid, Pralsetinib, Progesterone, Quercetin, Quinidine, Quinine, Remdesivir, Reserpine, Rifampicin, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rosiglitazone, Rosuvastatin, Rucaparib, Sacubitril, Saquinavir, Sildenafil, Silibinin, Simeprevir, Simvastatin, Sirolimus, Sorafenib, Sulfasalazine, Tacrolimus, Taurocholic acid, Telaprevir, Telithromycin, Teriflunomide, Tipranavir, Tirbanibulin, Troglitazone, Ubrogepant, Upadacitinib, Valsartan, Valspodar, Velpatasvir, Venetoclax, Verapamil, Vinblastine, Vincristine, Voxilaprevir
3	Solute carrier organic anion transporter family member 1B1 inducers	Apalutamide, Cholic Acid, Taurocholic acid
4	Solute carrier organic anion transporter family member 1B1 weak inhibitors	Cobimetinib
5	Solute carrier organic anion transporter family member 1B1 transporters	Velpatasvir

	Interacting Group	Interacting Drugs
	Istradefylline is a Solute carrier organic anion transporter family member 1B3 inhibitor
1	Solute carrier organic anion transporter family member 1B3 substrates	Ambrisentan, Atorvastatin, Belantamab mafodotin, Bempedoic acid, Caspofungin, Cholecystokinin, Cholic Acid, Cobimetinib, Conjugated estrogens, Docetaxel, Empagliflozin, Erythromycin, Fexofenadine, Fluvastatin, Gadoxetic acid, Glecaprevir, Grazoprevir, Letermovir, Levomenol, Levosalbutamol, Liothyronine, Liotrix, Methotrexate, Mycophenolate mofetil, Olmesartan, Ouabain, Paclitaxel, Parachlorophenol, Paritaprevir, Pitavastatin, Prasterone, Pravastatin, Raloxifene, Revefenacin, Rifampicin, Romidepsin, Selexipag, Simeprevir, Sincalide, Taurocholic acid, Technetium Tc-99m mebrofenin, Tenofovir alafenamide, Testosterone, Trastuzumab deruxtecan, Ubrogepant, Valsartan, Voxilaprevir
2	Solute carrier organic anion transporter family member 1B3 inhibitors	Asunaprevir, Ataluren, Atazanavir, Baricitinib, Beclomethasone dipropionate, Bempedoic acid, Bortezomib, Cabazitaxel, Clarithromycin, Cobicistat, Cobimetinib, Cyclosporine, Dabrafenib, Daclatasvir, Darolutamide, Dipyridamole, Dovitinib, Dronedarone, Elexacaftor, Enasidenib, Erythromycin, Everolimus, Fedratinib, Fostemsavir, Gemfibrozil, Ginsenoside Rb1, Glecaprevir, Idelalisib, Ivermectin, Levothyroxine, Lonafarnib, Lopinavir, Lurbinectedin, Mifepristone, Nefazodone, Nelfinavir, Novobiocin, Nystatin, Paritaprevir, Pexidartinib, Pibrentasvir, Pioglitazone, Pralsetinib, Remdesivir, Rifampicin, Rifamycin, Rilpivirine, Rimegepant, Ritonavir, Rucaparib, Sacubitril, Selinexor, Silibinin, Simeprevir, Sulfasalazine, Telithromycin, Tipranavir, Tirbanibulin, Ubrogepant, Valspodar, Velpatasvir, Vincristine, Voxilaprevir
3	Solute carrier organic anion transporter family member 1B3 transporters	Velpatasvir
4	Solute carrier organic anion transporter family member 1B3 inducers	Clotrimazole, Progesterone

	Interacting Group	Interacting Drugs
	Istradefylline is a Solute carrier family 22 member 6 inhibitor
1	Solute carrier family 22 member 6 inhibitors	Acetazolamide, Acetylsalicylic acid, Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Aminophenazone, Amoxicillin, Antipyrine, Aspartame, Ataluren, Baricitinib, Benzylpenicillin, Bumetanide, Cabotegravir, Caprylic acid, Captopril, Carbenicillin, Carprofen, Caspofungin, Cefacetrile, Cefadroxil, Cefalotin, Cefamandole, Cefazolin, Cefoperazone, Cefotaxime, Cefotiam, Cefradine, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalexin, Chloramphenicol, Chlorothiazide, Chlorpropamide, Cidofovir, Cilastatin, Cimetidine, Cinoxacin, Cloxacillin, Cyclosporine, Cyclothiazide, Dabrafenib, Diclofenac, Diflunisal, Dinoprostone, Dolutegravir, Doxycycline, Ellagic acid, Enalapril, Enasidenib, Etacrynic acid, Ethoxzolamide, Etodolac, Favipiravir, Flufenamic acid, Fluorescein, Flurbiprofen, Folic acid, Foscarnet, Furosemide, Ganciclovir, Gentamicin, Glutaric Acid, Glyburide, Hydrochlorothiazide, Hydroflumethiazide, Ibuprofen, Indomethacin, Ketoprofen, Latanoprost, Lenvatinib, Losartan, Meclofenamic acid, Methazolamide, Methotrexate, Minocycline, Nafcillin, Nalidixic acid, Naproxen, Nateglinide, Norfloxacin, Novobiocin, Ofloxacin, Osilodrostat, Oxyphenbutazone, Oxytetracycline, Phenacetin, Phenylbutazone, Piperacillin, Piroxicam, Pralsetinib, Pravastatin, Probenecid, Riboflavin, Rifampicin, Rucaparib, Salicylic acid, Silibinin, Streptomycin, Sulindac, Tafamidis, Taurocholic acid, Tazobactam, Tetracycline, Tolbutamide, Tolmetin, Topiroxostat, Trifluridine, Valproic acid
2	Solute carrier family 22 member 6 inducers	Furosemide
3	Solute carrier family 22 member 6 substrates	Acyclovir, Adefovir dipivoxil, Alprostadil, Aminohippuric acid, Bumetanide, Captopril, Cefacetrile, Cefaloridine, Cefazolin, Cefdinir, Cefotiam, Ceftibuten, Ceftizoxime, Cephalexin, Cidofovir, Cimetidine, Citrulline, Conjugated estrogens, Cyclic adenosine monophosphate, Cyclosporine, Didanosine, Dinoprostone, Edaravone, Ellagic acid, Famotidine, Fluorescein, Glutaric Acid, Grepafloxacin, Hydrochlorothiazide, Hydroflumethiazide, Indomethacin, Lamivudine, Latanoprost, Methotrexate, Oxytetracycline, Polythiazide, Probenecid, Silibinin, Stavudine, Taurocholic acid, Tazobactam, Tenofovir, Tenofovir alafenamide, Tenofovir disoproxil, Trifluridine, Ubrogepant, Zalcitabine, Zidovudine

	Interacting Group	Interacting Drugs
	Istradefylline is a POU domain, class 2, transcription factor 2 inhibitor
1	POU domain, class 2, transcription factor 2 inhibitors	Bictegravir, Fedratinib
2	POU domain, class 2, transcription factor 2 substrates	Nadolol

	Interacting Group	Interacting Drugs
	Istradefylline is a Multidrug and toxin extrusion protein 1 inhibitor
1	Multidrug and toxin extrusion protein 1 substrates	Acyclovir, Cefradine, Cephalexin, Cimetidine, Ciprofloxacin, Emtricitabine, Estrone sulfate, Flecainide, Ganciclovir, Guanidine, Levofloxacin, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Tetraethylammonium, Tipiracil, Topotecan, Trimethoprim
2	Multidrug and toxin extrusion protein 1 inhibitors	Abemaciclib, Apalutamide, Bictegravir, Brigatinib, Capmatinib, Cimetidine, Ciprofloxacin, Famotidine, Fedratinib, Flecainide, Gilteritinib, Glasdegib, Guanfacine, Lasmiditan, Levofloxacin, Lofexidine, Methylene blue, Osilodrostat, Pemigatinib, Pexidartinib, Plazomicin, Pralsetinib, Pyrimethamine, Ranolazine, Remdesivir, Rifamycin, Rimegepant, Ripretinib, Risdiplam, Rucaparib, Selpercatinib, Tafenoquine, Tazemetostat, Tirbanibulin, Topotecan, Trimethoprim, Tucatinib, Verapamil

	Interacting Group	Interacting Drugs
	Istradefylline is a Multidrug and toxin extrusion protein 2 inhibitor
1	Multidrug and toxin extrusion protein 2 substrates	Acyclovir, Baricitinib, Cimetidine, Estrone sulfate, Ganciclovir, Metformin, N-methylnicotinamide, Nadolol, Procainamide, Relebactam, Topotecan, Trastuzumab deruxtecan, Trimethoprim
2	Multidrug and toxin extrusion protein 2 inhibitors	Abemaciclib, Apalutamide, Baricitinib, Brigatinib, Capmatinib, Cimetidine, Ciprofloxacin, Copanlisib, Fedratinib, Glasdegib, Lasmiditan, Levofloxacin, Methylene blue, Pexidartinib, Plazomicin, Pralsetinib, Pyrimethamine, Ranolazine, Risdiplam, Rucaparib, Tafenoquine, Tazemetostat, Tirbanibulin, Trimethoprim, Tucatinib, Verapamil